多柔比星脂质体注射液与多柔比星注射液大鼠重复.pdf

锛掞紣锛戯紪骞达紪鏈 涓浗姣旇緝鍖诲鏉傚織 锛綍锝庯絽锛岋紥锛愶紤锛 绗紥锛栧嵎銆€ 绗紪鏈 锛ｏ绩锛╋籍锛ワ汲锛 锛集锛碉疾锛肌锛 锛鸡 锛ｏ集锛及锛★疾锛★即锛╋级锛 锛讥锛わ缉锛ｏ缉锛讥 锛讹綇锝岋紟 锛掞紪銆€ 锛綇锛 锛 矶嬳磱泶嬳磱泶嬳秼泶 泶 鐮旂┒鎶ュ憡矶 矶嬳磱泶嬳磱泶 澶氭煍姣旀槦鑴傝川浣撴敞灏勬恫涓庡鏌旀瘮鏄熸敞灏勬恫 澶ч紶閲嶅缁欒嵂姣掓€х殑姣旇緝 锛 锛 锛 寮犮€€ 棰 锛岄┈鐜夊 锛屾埓鏅撹帀 锛堬紤锛庡北涓滅渷涓存湊鍘夸汉姘戝尰闄紝灞变笢 涓存湊銆€ 锛掞紪锛掞紪锛愶紣锛涳紥锛庡北涓滅渷鑽绉戝闄紝娴庡崡銆€ 锛掞紩锛愶紤锛愶紣锛 銆€ 銆€ 銆愭憳瑕併€戙€€ 鐩殑銆€ 鐮旂┒澶ч紶杩炵画闈欒剦娉ㄥ皠缁欎簣澶氭煍姣旀槦鑴傝川浣撴敞灏勬恫鍜屽鏌旀瘮鏄熸敞灏勬恫鍚庡澶ч紶浜х敓鐨勬瘨 鎬т綔鐢ㄥ強姣掓€у紓鍚屾瘮杈冦€ 鏂规硶銆€ 锛筹激澶ч紶锛欙紣 鍙紝闅忔満鍒嗕负婧跺墏瀵圭収缁勩€佸鏌旀瘮鏄熻剛璐ㄤ綋娉ㄥ皠娑诧紙锛戯綅锝囷紡 锝嬶絿锛夊拰澶氭煍姣 鏄熸敞灏勬恫锛堬紤锝嶏絿锛 锝嬶絿锛夌粍銆 鍚勭粍澶ч紶姣忥紦 锝勯潤鑴夋敞灏勶紤娆★紝杩炵画缁欒嵂 锛戯紦娆★紝妫€娴嬪叾浣撻噸銆佽娑茬敓鍖栧銆佽娑插銆佽剰鍣ㄧ郴 鏁扮瓑鎸囨爣锛屽苟杩涜缁勭粐鐥呯悊瀛︽鏌ャ€ 缁撴灉銆€ 澶氭煍姣旀槦鑴傝川浣撴敞灏勬恫锛戯綅锝囷紡 锝嬶絿鍙紩璧凤汲锛ゅぇ榧犺劚姣涘拰婧冪枴锛屼綋閲嶅闀 鏄庢樉寤剁紦锛岋及锛即銆侊肌锛即銆侊饥锛碉籍鍗囬珮锛岋肌锛饥闄嶄綆锛屽績鑴忓拰鑲捐剰绯绘暟澧炲ぇ锛岃兏鑵哄拰鐫句父绯绘暟鍑忓皬锛岀粍缁囩梾鐞嗗妫€鏌ョ粨鏋滄樉绀 鐫句父鏇茬粏绮剧鐢熺簿涓婄毊鑴辫惤锛屽悇绾х敓绮剧粏鑳炴秷澶憋紝閮ㄥ垎闂磋川姘磋偪锛涘績鑴忓績鑲岀氦缁存柇瑁傘€佹憾瑙ｏ紝妯汗鍙婇儴鍒嗙粏鑳炴牳娑 澶憋紱鑲捐剰鍑虹幇鑲惧皬绠￠€忔槑绠″瀷绛夌梾鐞嗙粍缁囧鐥呭彉銆 涓庡鏌旀瘮鏄熻剛璐ㄤ綋娉ㄥ皠娑叉瘮杈冿紝鐩稿悓鍓傞噺涓嬪鏌旀瘮鏄熸敞灏勬恫浜 鍙紩璧蜂互涓婄梾鍙橈紝浣嗗ぇ榧犺劚姣涘拰鐨偆婧冪枴鐜囬檷浣庯紝鑲捐剰姣掓€у拰蹇冭剰姣掓€ф槑鏄惧鍔犮€ 缁撹銆€ 澶氭煍姣旀槦鑴傝川浣撴敞灏勬恫 涓庢櫘閫氭敞灏勬恫姣旇緝锛屽績鑴忓拰鑲捐剰姣掓€ф槑鏄惧噺杞伙紝浣嗙毊鑲ゆ瘨鎬ф槑鏄惧鍔犮€ 銆愬叧閿瘝銆戙€€ 澶氭煍姣旀槦娉ㄥ皠娑诧紱鑴傝川浣擄紱锛筹激澶ч紶锛涢噸澶嶇粰鑽瘨鎬 銆愪腑鍥惧垎绫诲彿銆 锛测亙锛擄紦銆€ 銆€ 銆愭枃鐚爣璇嗙爜銆 锛°€€ 銆€ 銆愭枃绔犵紪鍙枫€戯紤锛栵紬锛戔亙锛楋紭锛曪紪锛堬紥锛愶紤锛栵級锛愶紪鈦冿紣锛愶紥锛撯亙锛愶紩 锝勶綇锝夛細锛戯紣矶帮紦锛欙紪锛欙紟锝婏紟锝夛綋锝擄綆锛庯紤锛栵紬锛戯紞锛楋紭锛曪紪矶 锛掞紣锛戯紪矶帮紣锛栱栋锛愶紣锛 锛ｏ綇锝嶏綈锝侊綊锝夛綋锝忥綆 锝忥絾 锝旓綀锝 锝掞絽锝愶絽锝侊綌锝咃絼 锝勶綇锝擄絽 锝旓綇锝橈綁锝冿綁锝旓綑 锝忥絾 锝勶綇锝橈綇锝掞綍锝傦綁锝冿綁锝 锝岋綁锝愶綇锝擄綇锝嶏絽 锝夛綆锝婏絽