噬体的遗传分析.pptxVIP

第五章???? 噬菌体的遗传分析 Bacteriophage Genetics;第一节????? 噬菌体的繁殖和突变型 Life cycle and mutants of phages;Genetic material in a phage ;一、烈性噬菌体（ virulent phage）;;Life cycle;Lytic development is controlled by a cascade ( 裂解周期中基因产物的多级调节 ) ◆早期：由宿主RNA多聚酶转录噬菌体基因，产物主要为RNA多聚酶，δ因子或反终止因子 ◆中期：早期基因产物转录中期基因，产物为δ因子或反终止因子、复制酶等 ◆晚期：中期基因产物转录晚期基因，产物为新的噬菌体组装所需的各个组分。 ;;二、温和噬菌体（temperate phage);;;;Integration of λchromosome initiate the lysogenic cycle;Lysogenic bacterium are immune to further injection by the same phage;The λ repressor protein is responsible for maintaining lysogenic state and for immunity