Meta分析-Cochrane.pptVIP

* Funnel Plot Sample size Favors Treatment Favors Control Odds Ratio * * Cumulative Meta-analysis cumulative meta-analysis of trials comparing aprotinin to placebo to decrease bleeding with cardiac surgery 64 trials identified how do you interpret this information? * Observational Study Aprotinin * Publication Bias (again) FDA safety review, ‘Black Box’ warning Bayer pharmaceuticals 67 000 observational patient study increased risk for death, kidney failure, CHF, CVA not disclosed to FDA at time of review RCT underway comparing TXA to aprotinin * Ris