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胎盘生长因子介导小细胞肺癌细胞穿过血脑屏障的体内分析
·英文论著摘要·
ofPLGFinsmallcell cancer
Involvement lung
blood--brainbarrierin
migrationthrough vivo
Purpose
Fromthe accountfor 10%~
epidemiologyinvest,cancel"patiensapproximately
20%ofbrainmetastases in latestbrainmetastasescasesiS
cases,andChinese,the
1 of
about7000 allkindsbrainmetastases with cancer
peryear.In cases,patientslung
accountfor 30%ofbrainmetastasescases.More cell
approximately specially,small
the to and metastasize
lungcancer(SCLC)haspropensityprogressaggressivelyearly
tobrain.Brainmetastasesareasourceof and in
significantmorbiditymortalitypatients
wim investethemechanismhowSCLCcellmetastasestobrainis
SCLC.So,to of very
toSCLC’S andcure。
significanceprevention
in
metastasesare cellsflowed
However,cancer complectedpatho·stepes.Cancer
bloodtodistant extravasatefrombloodvesselsto
get organ,whichfirstly parenchyma.
Thus,the effectescancercellsmetastses.Aeventofbrain
vascellum’permeability key
metastasesisthatSCLCcells acrosstheblood-brain
migrate
bloodfromthebrain hadobservedthattheactivationof
separates parenchyma.We
in
Rho/ROCK humanbrainmicrivascularendothelial
signaling
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