以田鼠作为动物模型来研究社会行为的进化基因、脑与行为3.PDF

动物学报 　50 (4) :479 - 489 , 2004 A cta Zoologica S inica 　　　　　 　 Vole species as an animal model for the evolution of social behav ior : from genes to brain to behavior Miranda M. L IM , Elizabeth A. D. HAMMOC K , Larry J . YOUN G Center for Behavioral Neuroscience , Department of Psychiatry and Behavioral Sciences , Emory University , Atlanta , GA 　30322 , USA Abstract 　The vole genus Microtus shows extraordinary diversity in the range of social behaviors among closely related species. A few species , such as Microtus ochrogaster and pinetorum (prairie and pine vole) , show monogamous social or ganization , while other species such as Microtus montanus and pennsylvanicus (montane and meadow vole) are solitary and promiscuous. Monogamous prairie and pine voles display selective and longlasting pair bond formation between adult mates and biparental care of the offspring both in nature as well as in the laboratory. The neuropeptide vasopressin is in volved in the neural regulation of monogamous behavior in vole species. Here , we review the past and current findings re lated to the vasopressin system and pair bond formation in voles. First , we review vole species differences in the distribu tion of vasopressin V1a receptors (V1aR) in the brain as a means to identify the role of specific brain regions in pair bond formation. Next , we discuss pharmacological manipulations with V1aR antagonist administered into specific brain regions to determine which regions are necessary for pair bond formation. We also describe vole species differences in V1aR gene structure and function and potential contribution