astrocyte(星形胶都质细胞).pptVIP

* * Astrocyte Reactivity to Unconjugated Bilirubin Requires TNF-α and IL-1β Receptor Signaling Pathways GLIA 59:14–25 (2011) SCI(2010)：5.19 周康康 2012-7-2 1 We have reported that tumor necrosis factor (TNF)-α and interleukin (IL)-1β are produced by cultured neurons and mainly by glial cells exposed to unconjugated bilirubin (UCB). The effects of these cytokines are mediated by cell surface receptors through a nuclear factor (NF)-κB-dependent pathway that we have showed to be activated by UCB. Summary 2 Exposure of astrocytes to UCB increased the expression of both TNF- α recep