库欣综合-曾正陪.pptVIP

库欣综合征 曾正陪 北京协和医院内分泌科 In 1912, a physician by the name of Harvey Cushing described eight patients with central body obesity, glucose intolerance, hypertension, excess hair growth, osteoporosis, kidney stones, menstrual irregularity, and emotional liability.It is now known that these symptoms are the result of excess production of cortisol by the adrenal glands. 库欣综合征（Cushing’s syndrome）又称皮质醇增多症，或柯兴综合征，是由于肾上腺皮质长期分泌过量皮质醇引起的症候群，这称为自发性库欣综合症。长期应用外源性糖皮质激素或饮用酒精饮料也可引起类似库欣综合征临床表现，称为类库欣综合征。 库欣综合征的发现 肾上腺的结构 球状带 束状带 网状带 髓质 ACTH依赖性 ACTH Dependent (80%) 垂体或垂体以外的某些肿瘤组织分泌过量ACTH，使双侧肾上腺皮质增生并