中间纤维蛋白vimentin突变体e151力k病理机制的分析-细胞生物学专业毕业论文.docxVIP

ABSTRACTVimentin ABSTRACT Vimentin is a highly conserved type III intermediate filament protein． Intermediate filament is a major component of cytoskeleton，working together with microtubules to support and maintain the normal positioning of cellular organelles，correct connection between cells and proper adhesion，as well as migration of vertebrate cells． Genetic cataract is one of the major causes for blindness． Mutations in the genes coding for structure proteins，transcription factors，membrane proteins and ion channels all cause genetic cataract．It has been shown that the point mutation G596A