HEPATITISVIRUSES肝是炎病毒.pptVIP

HEPATITIS VIRUSES肝炎病毒 Hepatitis A virus，HAV甲型肝炎病毒 Biological Properties picornavirus, +ssRNA genome小RNA病毒科 27 nm in diameter ,non-enveloped icosahedral particle 27nm, 球形， 20面立体对称，无包膜 one serotype一个血清型 Pathogenesis致病性 spread via the fecal-oral route粪－口途径传播 Source of infection: patient, inapparent infection传染源: 病人、隐性感染者 Viral shedding in the stool precedes the onset of symptoms by 14d but stops before the cessation of symptoms Symptoms Initial symptoms: fever, fatigue, nausea, loss of appetite, abdominal pain Jaundice HAV的致病性 Asymptomatic infections are very common. As