神经系统药理—魏尔清(抗帕金森病药.pptVIP

Levodopa 1. ADME Penetrating into the brain, transformed to DA or NE (less) Distributed in peripheral tissue (most) 2. Effects and uses Parkinson disease: decreases the rigidity, tremors, and other symptoms 3. Adverse effects (1) CNS: abnormal involuntary; hallucinations; etc. (2) GI: nausea, vomiting, etc. (3) CVS: hypotension, arrhythmia, etc. Inhibitors of aromatic L-amino acid decarboxylase Carbidopa 卡比多巴 can not cross BBB, but can inhibit peripheral dopamine synthesis. increases availability of levodopa to the CNS and decreases peripheral effects Other drugs 1. DA receptor agonists B