番茄红素对脑缺血再灌注大鼠氧化应激与缺氧损伤的影响.pdfVIP

ABSTRACT Objective： StrokeisOtlUoltheseverest anddeathinhuman dealof cRtls,eg,ofdelbmfity Agreat studies caddadveis i}／dicatethat slrcssthe causativefactorsofneuron imporlant trauma oneoftheantioxidants aliert：erebmlischemia-reperfusioninjuryLycopeneis lndiet evidences that hasthe Aceumulatiing stronglysuggestlycopene protoction effi．-ctofcerebrovascular studiesshowthat is diseases，human serum[ycopene to relatedwithcardio—cerebrovasculardiseasesThis aimed negative study investigate the effectsof orl cerebral induced protection lycopene ischemia—roperfusioninjury by focalcerebralisdlemialnratsinoxidativestressandanoxic ways I TheestablishmentofMiddlecerebral arteryocclusion(MCAO) 20maleSD divided ratswei苎htin9260～2809wererandomlytowelghcintoA．B， C，D has5ratsThediameterofembolismthreadeach wcFe group．eachgroup group and0．28ramThemodelofcerebral 0,22mm，0．24ram，0．26mm ischemia—reperfusion establishedcerebral injurywas bymiddleartery diameterofembolismthreadsuccessfulrates befitting accordingtotheofeachgroup 2 Theeffects on in in cerebral rats oflycopene ischemia-reperfusioninjury and oxidativestressanoxic