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HMGB1 and RAGE in
Inflammation and Cancer
Gary P. Sims,1 Daniel C. Rowe,1 Svend T. Rietdijk,2
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r Ronald Herbst, and Anthony J. Coyle
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e 1Department of Respiratory, Inflammation and Autoimmune Disease, MedImmune,
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e One Medimmune Way, Gaithersburg, Maryland 20878; email: CoyleA@M
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a . 2 Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam,
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n n NL-1105 AZ, The Netherlands
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8 1 Annu. Rev. Immunol. 2010. 28:367–88 Key Words
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7 y First published online as a Review in Advance on
6 t high mobility group box 1, necrosis, S100 proteins, Toll-like
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3 s January 4, 2010
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8 e receptors, tolerance, autoimmune disease
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0 n The Annual Review of Immunology is online at
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2 t Abstract
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