qtof在食入品安全的应用.ppt

四极杆质谱 VS TOF 高灵敏度 串联四极杆MRM模式 高选择性 特定的MRM通道 高线形范围 定量“黄金标准” 法规依从性 一个通道定量，一个通道确认 内容 Waters QTof 特点 Waters QTof在食品药物残留快速筛查领域的应用 内容 Waters QTof 特点 Waters QTof在食品药物残留快速筛查领域的应用 1. 分辨率 精确质量 四级杆的分辨率不足以将两个化合物分开 ToF 具有 10,000的分辨率, 可以清晰的两个峰分开. 质量精度 2ppm 一张色谱图内的精确质量稳定性 Lockmass ：在线的UPLC/MS精确质量采集 仪器的质量校正 LockSpray UPLC/MSE所有数据，所有时间 Engineered Simplicity工程精简 创新的离子源设计 简便的设置 灵敏 稳定 IntelliStart: 简单的操作 所有的仪器校正和系统设置可以自动执行 创新的离子源设计 内容 Waters QTof 特点 Waters QTof在食品药物残留快速筛查领域的应用 Waters QTof在食品药物残留快速筛查领域的应用Food Screening 目标化合物筛查 半目标化合物筛查 未知化合物筛查 目标或半目标化合物筛查 目标化合物筛查关注的是那些需要限定含量的特定化合物 目标化合物筛查: 化合物在MS采集前设定好范围，范围外那些出现的化合物不会被检测 典型的是那些基于四极杆作为第一质量分析器的方法，比如MRM模式(QqQ)或者子离子扫描（QTOF） 半目标化合物筛查: 通用的数据采集，采集后指定需要筛查的化合物 主要是基于全扫描模式的方法，比如TOF 传统Q-Tof筛查的通用流程 This is the interface of ChromaLynx. The summary is given by the column on the left, that says if the residue has been found. Additional spectral information is also displayed, together with the extracted ion mass chromatogram ChromaLynx XS: Tells you the whether the retention time is within tolerance of what is stated in the list (this is optional as you may not know it) if the retention , and also the mass tolerance. Tell the list the molecular The red kite (family: accipitridae, latin name: milvus milvus) is a bird of prey that belongs to the same family as hawks, vultures and eagles. This species has approximately 18,000 – 24,000 current breading pairs in Europe, with around two thirds of this population found in Germany, and further significant populations in France and Spain. There are now just over 1,000 breeding pairs in the U.K., mainly located in central Wales, along the spine of central England and at various sites in Scotland. ? The red kite is primarily a scavenger that feeds on worms, small mammals and carrion. Its feeding habits make it particularly susceptible to pesticide poisoning, either accidental – when it feeds on creatures that have previously been killed by pesticides, or intentional – when people spike