二氢杨梅素药理作用研究进展.pdf

中草药 Chinese Traditional and Herbal Drugs 第 46 卷 第 4 期 2015 年 2 月 ·603 · 二氢杨梅素药理作用研究进展 侯小龙，王文清，施春阳，童 庆，方建国* 华中科技大学同济医学院附属同济医院 药学部，湖北 武汉 430030 摘 要：二氢杨梅素为藤茶中主要的黄酮类化合物，近年来其药理作用受到广泛关注。本文就 10 余年来二氢杨梅素抗肿瘤、 抗炎、抗氧化、解酒护肝、抗病原微生物、降血糖、抗疲劳和调血脂等方面的研究进展进行综述，为二氢杨梅素的深入研究 及其植物资源的进一步综合开发利用提供科学依据。 关键词：二氢杨梅素；黄酮类；抗肿瘤；抗氧化；抗炎 中图分类号：R285 文献标志码：A 文章编号：0253 - 2670(2015)04 - 0603 - 07 DOI: 10.7501/j.issn.0253-2670.2015.04.027 Research progress in pharmacological effects of dihydromyricelin HOU Xiao-long, WANG Wen-qing, SHI Chun-yang, TONG Qing, FANG Jian-guo Department of Pharmacy, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Abstract: As a major flavonoid in the leaves of Ampelopsis grossedentata , dihydromyricelin has attracted the wide attention in recent years. Studies showed that dihydromyricelin has multiple pharmacological effects, such as antitumor, anti-inflammation, anti-oxidation, blood lipid regulation, anti-temulence and liver protection, antidiabetics, and anti-pathogeny microorganism. We made a summary for domestic and foreign study literatures for various pharmacological effects of dihydromyricelin in the recent decade, in the expectation of providing the scientific basis for the in-depth studies, as well as the utilization of dihydromyricelin and its medicinal resource. Key words: dihydromyricelin; flavonoids; antitumor; anti-oxidation; anti-inflammation 二氢杨梅素 （dihydromyricelin，DMY 或 DHM ） 一步开发、利用和研究二氢杨梅素提供参考。 又称蛇葡萄素（ ampelopsin ，AMP ）、白蔹素 1 理化性质 （ampelopsin ）、双氢杨梅树皮素、双氢杨梅素、福 二氢杨梅素化学名称为 (2R,3R)-3,5,7-三羟基- 建茶素等，是一种二氢黄酮醇类黄酮化合物，1940 2-(3,4,5-三羟基苯基)苯并二氢吡喃-4-酮，分子式为 年，首先从蛇葡萄属植物楝叶玉葡萄 Ampelopsis C H O ，相对分子质量为 320.25 ；为白色针状结 15 12 8 meliaefolia (Hand. –