多重耐药草绿色链球菌脑膜炎合并菌血症抗感染-中国病理生理杂志.PDFVIP

. 592 . 中国抗生素杂志2018年5月第43卷第5期 文章编号：1001-8689(2018)05-0592-05 多重耐药草绿色链球菌脑膜炎合并菌血症抗感染用药分析 1 2 刘丽英 雷宏 (1 江西省赣州市妇幼保健院药剂科，赣州34 1000 ；2 江西省赣州市妇幼保健院检验科，赣州34 1000) 摘要：目的 探讨多重耐药草绿色链球菌脑膜炎合并菌血症的抗感染治疗方案。方法 通过临床药师参与1例多重耐药草 绿色链球菌脑膜炎合并菌血症的抗感染治疗，探讨细菌耐药机制，总结治疗方案。结果 对于多重耐药草绿色链球菌脑膜炎合 并菌血症，尽早获得脑脊液培养和血液培养结果，并结合脑脊液涂片、常规、生化是诊断草绿色链球菌脑膜炎的金标准。根据 药敏试验及时开始针对病原菌的治疗很关键。结论 多重耐药草绿色链球菌引起的脑膜炎发病率虽低，也不可忽视，如合并菌 血症可能与血行播散有关。获得明确病原学依据后推荐使用以万古霉素为基础的联用治疗方案。 关键词：多重耐药；草绿色链球菌脑膜炎；用药分析 中图分类号：R978.1；R969 文献标志码：A Analysis of anti-infection medication against multidrug-resistant Streptococcus viridans meningitis complicated with bacteremia 1 2 Liu Li-ying and Lei Hong (1 Department of Pharmacy, Mother and Childrens Hospital of Ganzhou,Ganzhou 341000; 2 Department of Clinical Laboratory, Mother and Childrens Hospital of Ganzhou, Ganzhou 341000) Abstract Obj ective To investigate the anti-infective treatment of multidrug-resistant Streptococcus viridans meningitis complicated with bacteremia. Methods We explored the mechanisms of bacterial resistance and summarized the therapeutic regimen according to the participation of clinical pharmacists in an anti-infection treatment of multidrug-resistant Streptococcus viridans meningitis complicated with bacteremia. Results The timely results of cerebrospinal fluid culture and blood culture as well as the synthesis of cerebrospinal fluid smear, routine and biochemical tests are the key diagnostic criteria. It is vital to carry out the treatment targeting the pat