基础研究BMP和TGF-对兔尺骨骨缺损修复作用的研究-中国骨伤.PDFVIP

148 2003 3 16 3 C ina J Ort op T rauma, Mar 2003, Vol. 16, No. 3 BMP TGF- 1 1 2 2 1 1 3 2 2 卢卫忠 贺小兵 唐康来 杨柳 朱庆和 刘小冬 何静 许建中 吴梅英 ( 1 , 408000; 2 ; 3 ) ! BMP T GF- 15 cm , T GF- BMP, 4812 X 12 , BMP / T GF- , , T GF- BMP T GF- BMP, BMP T GF- ; , T GF- BMP , , T GF- BMP BMP T GF- , BM P T GF- , , , ! ; ; ; The effects of exogenous bone morphogenetic protein and transforming growth factorbeta on repairing ulna defects in rabbits L U Weiz hong , H E X iaobing , TA N G K anglai , et al . Dep artment of Orthop aedi s , Chongqing Fuling Central H osp ital ( Chongqing , 408000, China) Abstract! Objective To investigate t e effects of exogenous bone morp ogenetic protein ( BMP) and t ransforming growt factorbeta ( T GF- ) on repairing bone defects Methods Adult rabbits were inflicted w it t e model of 15 cm segmental defect in t e rig t ulna and treated locally wit T GF- and BMP, alone or in combination in t e bone defect site.T e repair capability was evaluated by gross, istological and radio grap ic examinations at t e 4t , 8t and 12t week and by biomec anical tests at t e 12t w eek after opera tion. Results T e bone defects were all repaired in t e treatment groups, w ic could not be found in t e con trol group.T e repair w as better in cotreatment group w it T GF- and BMP t an in treatment groups w it T GF- or BMP alone respectively, w ereas BMP group w as better t an T GF- group. T e biomec anical strengt of t e ulna in t e cotreatment group w it BMP and T GF- w as approac ed to t at of normal bone, w ereas t at of treatment alone w it BMP or T GF- w as w eaker t an normal bone and T GF- group w as w eaker t an BMP group. Conclusion BMP and T GF- could promote repair of segmental bone defects and t e effect of BMP is better t a