Tau异常磷酸化与Tau病.pdfVIP

International Journal of Psychiatry and Neurology 国际神经精神科学杂志, 2017, 6(2), 7-12 Published Online May 2017 in Hans. /journal/ijpn /10.12677/ijpn.2017.62002 Abnormally Phosphorylated Tau and Tauopathies Yigang Chen Medical College, Wuhan University of Science and Technology, Wuhan Hubei th th th Received: May 6 , 2017; accepted: May 24 , 2017; published: May 27 , 2017 Abstract Tau is the very important microtuble-associated protein in the brain. Abnormally phosphorylated tau plays an important effect. Tauopathy is a total name of the diseases aroused by abnormal tau protein, being the neurodenatured diseases with the accumulation of abnormally phosphorylated tau in the neural cells and neuroglias. The hyper-phosphorylation at some regions of tau may af- fect the binding ability of tau with the microtuble, and being severer, the hyper-phosphorylation can improve and enhance the accumulation of tau. There are many evidences, that manifested the hyper-phosphorylation of tau protein may happen in the most early stage in the pathological courses of Alzheimer’s disease and the other diseases caused by the abnormal tau protein. Hy- per-phosphorylation of tau protein can be caused by the up-regulation of the activity in the pro- tein kinases or the down-regulation of the activity in the protein phosphatases. It is still not clear how do happen the neurodegenerative diseases such as AD and so on. The deep researches about the relative function and regulation-control mechanism of tau protein maybe provide some new thinking for us understanding the clinic and pathophysiological mechanism, and offer certain bases for the diagnosis and treatment in the early stage of the diseases.