健康青年人血管内皮功能及动脉弹性的MRI测量研究.docVIP

健康青年人血管内皮功能及动脉弹性的MRI测量研究 贾 颖，陈金华，李 雪，张玉龙，向建波，方靖琴，王舒楠，张伟国（400042 重庆，第三军医大学大坪医院野战外科研究所放射科） [摘要]目的 评价MRI在测定血管内皮功能及动脉弹性中的作用，探讨各指标正常值参考范围。方法 选取26例年龄范围为（20～22）岁的26例完全健康的男性青年志愿者，利用3.0T MRI的稳态自由进动快速成像(fast imaging with steady state free precession，TureFISP）电影序列扫描，测量动脉内皮依赖性舒张功能(flow-mediated dilation, FMD)及主动脉可扩张性(aortic distensibility , AD)。 结果 股动脉FMD值为（11.26±+2.67）%；升主动脉（ascending aorta，AA）在心脏收缩末期的最大面积为（600.9±115.7）mm2，心脏舒张末期的最小面积为（449.2±92.3）mm2，AD值为（10.04±3.29）×10-3/mmHg；近段降主动脉（proximal descending aorta，PDA）在心脏收缩末期的最大面积为（369.6±59.8）mm2，心脏舒张末期的最小面积为（287.4±59.7）mm2，AD值为（8.54±4.78）×10-3 /mmHg；远段降主动脉（distal descending aorta，DDA）在心脏收缩末期的最大面积（310.7±58.1）mm2，心脏舒张末期的最小面积为（221.9±41.2）mm2，AD值为（11.80±4.56）×10-3 /mmHg。比较股动脉平静状态舒张末期直径及加压后舒张末期直径，差异有统计学意义（P0.01），升主动脉、近段降主动脉、远段降主动脉3组收缩末期的最大面积及舒张末期的最小面积值比较均有显著差异（P0.01）。结论 利用MRI测量血管内皮功能及动脉弹性的各项指标，安全、无创、组织分辨力高、重复性好，有利于血管疾病的早期检出，可为临床早期干预治疗提供依据。 [关键词] 核磁共振成像；内皮功能；动脉弹性 [中图法分类号] R445.2；R816.2 [文献标志码] A Assess the vVascular endothelium functions and arterial flexibility by MRI in health youth: a fundamental study Jia Ying, Chen Jinhua, Li Xue, Zhang Yulong, Xiang Jianbo, Fang Jingqin, Wang Shunan, Zhang Weiguo（ (Department of Radiology, Institute of Surgery Research, DapingThird Affiliated Hospital, and Research Institute of Surgery, Third Military Medical University, Chongqing, 400042, China） [Abstract] Objective To evaluate the role of MRI in determining vascular endothelium functions and arteryial flexibility and obtain normal reference ranges of each index. Methods A total of 26 healthy male young volunteers, aging from 20 to 22, were enrolled in this study. Selected 26 healthy male young volunteers aged from 20 to 22 years, measuredTheir flow-mediated dilation (FMD) and aortic distensibility (AD) were measured by 3.0T MRI through using fast imaging with steady state free precession（ (TureFISP）) sequence. Results FMD value of femoral artery was （(11.26±2.67）)%；. tThe largest area of ascending aorta（ (AA）), proximal descending aorta