第7章细胞质手基质与内膜系统.ppt

* * Schematic representation of the ubiquitin-proteasome pathway and the secretory pathway with the quality control machinery that dislocate misfolded proteins from the ER. The acronyms of the transcripts contained in IMP1 granules are indicated in red. For full names refer to Table I (1). Proteins to be glycosylated enter the ER in an unfolded state upon co-translational translocation through the heterotrimeric Sec61 channel. Nascent polypeptides are covalently modified by attachment of high mannose core oligosaccharides. N-Linked glycosylation is carried out by the oligosaccharyltransferase