滤泡辅助性T细胞分化和功能的研究进展.PDF

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滤泡辅助性T细胞分化和功能的研究进展.PDF

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22 6 Vol. 22, No. 6 2010 6 Chinese Bulletin of Life Sciences Jun., 2010 1004-0374(2010)06-0529-05 T (200031) T (T follicular helper cells, TFH )CD4+ T B B T T T ; Q25 7 A The progress on differentiation and function of T follicular helper cells WU Xiao-dong, LI Zhen-hu, SUN Bing * (Institute of Biochemistry and Cell Biology, Shanghai Intitutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China) Abstract: A newly identified subset of T cells, termed T follicular helper (TFH) cells , has a unique ability to home to B cell follicles and to induce antibody production by B cells. In the past few years, there has been a surge of research aimed at understanding the function and differentiation of these important cells. This Review focuses on the current progress in TFH cell biology Keywords T follicular helper cells; differentiation; humoral immunity; antibody production B (class switch) B B T T (T follicular CD4+ T helper cells, TFH ) [7, 8] (GC)B CXCR5CXCR5 (somatic hypermutation) BCL-6TFH (class switch recombination) TFH (affinity maturation) ( IL-21IL-4) ICOS B [1, 2] (inducible T cell co-stimulator)PD-1CD40L CD4T B B TFH T T IL-10 CXCL13(CXCR5 )[9,10] [3] T B IL-10 B [4 ] 1TFH 30B + T [5, 6] CD4 T T 2010-06-10 * E-mail: bsun@sibs.ac.cn