爱必妥作用机制及不良反应处理.pptVIP

* 伊利替康：喜树碱；阿糖胞苷：吉西他滨；蒽环类：阿霉素 * 很多临床前试验显示了爱必妥与化疗药物或放疗联合应用，对放化疗的増敏作用。 - Non-clinical studies have shown that 爱必妥? has excellent activity in colorectal tumor model systems in vitro and in vivo.[1–4] 爱必妥? induced DiFi colon cancer cells to undergo apoptosis. The apoptosis was associated with the activation of the apoptosis-initiating caspases, caspase-8 and -9.[4] - 爱必妥? led to a dose-dependent inhibition of the potent angiogenesis-stimulating growth factor, vascular endothelial growth factor (VEGF), in human GEO colon cancer cells in vitro. In GEO xenografts, 爱必妥? reduced microvessel count (a hi