两亲性壳聚糖衍生物在药物递送中的研究进展-药学研究.PDF

鑽鐮旂┒ 淼帮吉锝忥綍锝掞綆锝侊綄 锝忥絾 锛帮綀锝侊綊锝嶏絹锝冿絽锝曪綌锝夛絻锝侊綄锛诧絽锝擄絽锝侊綊锝冿綀 锛掞紣锛戯紭 锛讹綇锝?锛擄紬陰籍锝?锛 淼帮紩锛擄紩 淼 涓や翰鎬у３鑱氱硸琛嶇敓鐗╁湪鑽墿閫掗€佷腑鐨勭爺绌惰繘灞 鐢版槬鑾夑幀闉犳浌浜戧幀寮犵伩 (涓浗鑽澶у鏂拌嵂鐮旂┒涓績陰睙鑻忕渷浠ｈ阿鎬х柧鐥呴噸鐐瑰疄楠屽陰睙鑻 鍗椾含锛掞紤锛愶紣锛愶紮) 鎽樿:澹宠仛绯栨槸涓€绉嶆潵婧愪赴瀵岀殑纰辨€у绯栮幀鍏锋湁鑹ソ鐨勭敓鐗╃浉瀹规€у拰鐢熺墿鍙檷瑙ｆ€ш幀浣嗘槸鍏跺樊鐨勬憾瑙ｆ€ч檺鍒朵簡 澹宠仛绯栧湪鍖昏嵂棰嗗煙鐨勫簲鐢幃 涓轰簡鎻愰珮澹宠仛绯栫殑婧惰В鎬ш幀鐮旂┒鑰呭澹宠仛绯栬繘琛屼袱浜叉€ф敼鎬ш幀閫氳繃閫夋嫨涓嶅悓鐨勪翰姘淬€佺枏 姘村熀鍥㈥幀璁捐鍚堟垚浜嗕袱浜叉€у３鑱氱硸琛嶇敓鐗╆幃 骞跺埄鐢ㄥ叾鍦ㄦ按婧舵恫涓殑鑷粍瑁呮€ц兘陰舰鎴愪袱浜叉€у３鑱氱硸绾崇背绮掙幀鐢ㄤ簬澶 绉嶈嵂鐗╃殑閫掗€侁幀浠ヨ揪鍒板鍔犺嵂鐗╂憾瑙ｆ€с€佺ǔ瀹氭€с€侀檷浣庤嵂鐗╂瘨鎬у拰鎻愰珮鐢熺墿鍒╃敤搴︾瓑鐩殑陰 鏈枃缁艰堪浜嗕袱浜叉€у３鑱 绯栬鐢熺墿鐨勫悎鎴愭柟娉曣幀浠ュ強鍏跺湪鑽墿閫掗€佺郴缁熶腑鐨勫簲鐢幃 鍏抽敭璇岤澹宠仛绯栬鐢熺墿陰讳袱浜叉€ш幓鍚堟垚鏂规硶陰昏嵂鐗╅€掗€佺郴缁 锛 锛 锛 涓浘鍒嗙被鍙耳锛诧紮锛旓紨銆€ 鏂囩尞鏍囪瘑鐮?锛°€€ 鏂囩珷缂栧彿:锛掞紣锛欙紩 锛曪紦锛楋紩(锛掞紣锛戯紭)锛愶紮 锛愶紩锛擄紩 锛愶紣锛 锝勶綇锝堹锛戯紣.锛戯紦锛曪紣锛? 锝?锝冿綆锝嬶綁.锝婏綈锝?锛掞紣锛戯紭.锛愶紮.锛愶紤锛 锛诧絽锝擄絽锝侊綊锝冿綀 锝愶綊锝忥絿锝掞絽锝擄綋 锝忥綆 锝侊綅锝愶綀锝夛綈锝堬綁锝岋綁锝 锝冿綀锝夛綌锝忥綋锝侊綆 锝勶絽锝掞綁锝栵絹锝旓綁锝栵絽锝 锝夛綆 锝勶綊锝曪絿 锝勶絽锝岋綁锝栵絽锝掞綑 锛达缉锛★籍 锛ｏ綀锝曪綆锝岋綁陰吉锛碉迹锝侊綇锝欙綍锝庩幀锛猴绩锛★籍锛 锛ｏ絹锝 (锛綁锝侊綆锝囷綋锝曪极锝咃綑 锛絹锝傦綇锝掞絹锝旓綇锝掞綑 锝忥絾 锛わ綊锝曪絿 锛わ綁锝擄絻锝忥綎锝咃綊锝欙絾锝忥綊 锛絽锝旓絹锝傦綇锝岋綁锝 锛わ綁锝擄絽锝侊綋锝咃綋陰迹锝咃綆锝旓絽锝 锝忥絾 锛わ綊锝曪絿 锛わ綁锝擄絻锝忥綎锝咃綊锝欔幀 锛ｏ綀锝夛綆锝 锛帮綀锝侊綊锝嶏絹锝冿絽锝曪綌锝夛絻锝侊綄 锛碉綆锝夛綎锝咃綊锝擄綁锝旓綑陰籍锝侊綆锝婏綁锝庯絿 锛掞紤锛愶紣锛愶紮陰迹锝堬綁锝庯絹) 锛★絺锝擄綌锝掞絹锝冿綌:锛ｏ綀锝夛綌锝忥綋锝侊綆 (锛ｏ汲)锝夛綋 锝 锝庯絹锝旓綍锝掞絹锝 锝侊綄锝嬶絹锝岋綁锝庯絽 锝愶綇锝岋綑锝擄絹锝冿絻锝堬絹锝掞綁锝勶絽 锝楋綁锝旓綀 锝 锝掞綁锝冿綀 锝擄綇锝曪綊锝冿絽陰絽锝橈綀锝夛絺锝夛綌锝夛綆锝 锝囷綇锝忥絼 锝傦綁锝忥絻锝忥綅锝愶絹锝旓綁锝傦綁锝岋綁锝旓綑 锝侊綆锝 锝傦綁锝忥絼锝咃絿锝掞絹锝勶絹锝傦綁锝岋綁锝旓綑陰絺锝曪綌 锝愶綇锝忥綊 锝擄綇锝岋綍锝傦綁锝岋綁锝旓綑 锝岋綁锝嶏綁锝旓綋 锝夛綌锝 锝侊綈锝愶綄锝夛絻锝侊綌锝夛綇锝 锝夛綆锝旓綀锝咃絾锝夛絽锝岋絼锝忥絾 锝嶏絽锝勶綁锝冿綁锝庯絽.锛╋綆 锝忥綊锝勶絽锝 锝旓綇 锝忥綎锝咃綊锝冿綇锝嶏絽 锝夛綌锝 锝擄綀锝忥綊锝旓絻锝忥綅锝夛綆锝囷綋陰絹锝嶏浚 锝愶綀锝夛綈锝堬綁锝岋綁锝 锝冿綀锝咃綅锝夛絻锝侊綄 锝嶏綇锝勶綁锝嗭綁锝冿絹锝旓綁锝忥綆 锝忥絾 锛ｏ汲 锝夛綋 锝冿絹锝掞綊锝夛絽锝 锝忥綍锝旉幓锝傦綑 锝擄絽锝岋絽锝冿綌锝夛綆锝 锝勶綁锝嗭絾锝咃綊锝咃綆锝 锝堬綑锝勶綊锝忥綈锝堬綁锝岋綁锝 锝侊綆锝 锝堬綑锝勶綊锝忥綈锝堬綇锝傦綁锝 锝囷綊锝忥綍锝愶綋陰絹锝嶏綈锝堬綁锝愶綀锝夛綄锝夛絻