tlr7临激动剂imiquimod的研究进展.pptVIP

Imiquimod--a TLR7 agonist;Introduction; It was first identified as a compound that has anti-viral activity in pigs infected with herpes simplex virus, and has been successfully used for the treatment of genital warts caused by human papilloma virus in the clinical. Recent study revealed it also has direct proapoptotic activity against various tumor cell populations in vitro and in vivo.;the antiviral activity of imiquimod; resiquimod (S-28463), imiquimod (S-26308). Human peripheral blood mononuclear cells (PBMC);Mo-DC, dendritic cells (DC) derived from monocytes, plasmacytoid dendritic cells (pDC);Imiquimods proapoptotic effect in vitro;Imiquimod induces apoptosis by imiquimod dose-dependent and by pass of mitochondria-dependent in prostate cancer cells;A TLR7 inhibitor chloroquine does not restore the growth inhibition by imiquimod ;Imiquimod inhibits in vivo growth of prostate cancer in mice;the role of imiquimod in macrophage;TLR7 expressed in macrophages but not in SMCs;imiquimod induced cell apoptosis is dependent on TLR7;imiquimod induced macrophage autophagy by TLR7;Imiquimod-induced macrophage inflammation is TLR7 dependent;the role of imiquimod in atherosclerotic plaque;a Transmission electron-microscopic images of macrophages show autophagosome formation after imiquimod treatment for 7days. b Images of SMCs shown autophagosome formation after imiquimod treatment;I, intima; M, media; a, VCAM-1; b, T cells; c, macrophages;;TLR7/8 agonists as vaccine adjuvants; Mice vaccinated intradermally with microneedles coated with imiquimod and H1N1 HA induced IFN-γ-producing T-cell response, high levels of IgG2 and protective immunity following a lethal challenge with a mouse-adapted infuenza strain.;什么是Toll样受体？