近红外光介导的石墨烯基复合药物的构建与其抗癌效应分析.pdfVIP

ABSTRACT ABSTRACT Currently, it becomes an imperative requirement to develop a new and non-traditional therapeutic approach to treat cancers efficiently because conventional methods have many disadvantages. Photothemal therapy (PTT) and photodynamic therapy (P DT) are two new photo-therapies based on photothemal effect and ROS reaction and owe the merits of high selectivity, noninvasiveness, and efficiency. Particularly, near- infrared light (NIR) mediated PTT and PDT is being attached enormous attention, since NIR has low absorption by biological tissue and can penetrate deep tissue. On the other hand, nano graphene oxide (GO) has great potential in biomedicine due to their highly enriched physical and chemical properties, such as well biocompatibility, high surface ratio, rich oxygen-containing functional groups, easy functionalization. Therefore, study of NIR-responsive nanomedicine based on GO for PTT and PDT combination therapy is being considered as a promising strategy to high efficiently and non-invasively treat cancer. In this thesis, a kind of NIR active nanocomplex based on GO was developed for cancer synergistic PTT and PDT therapy. In brief, GO-CuS nanohybrides were synthesized through hydrothermal method, and stabilized with amphiphilic mPEG-DSPE. Characterization results of TEM, AFM, TGA, XRD, EDX and UV-vis-NIR showed that a large amount of CuS nanoparticles were dispersed on GO with a diameter of about 15nm; and hexahedral crystals. The height of PEG/GO-CuS is mainly in 30-40nm. Compared with GO, PEG/GO-CuS had a strong a