固体脂质纳米粒的石研究及应用.docVIP

PAGE PAGE 10 作者简介:刘春喜, 女, 硕士研究生 *通讯作者: 张娜, 女, 博士, 教授, 硕士生导师 Tel:0531 E-mail:zhangnancy9@ 固体脂质纳米粒的研究及应用 刘春喜1，张娜1* （1.山东大学药学院，济南 250012；） 摘要 自Müller 等人首次提出固体脂质纳米粒(solid lipid nanoparticles, SLN) 以来，SLN作为一种新型的脂质药物传输载体而备受关注。SLN用生理相容性的脂质或类脂质等常用的药剂辅料制备而成，综合了其他微粒传输系统如聚合物纳米粒、脂肪乳和脂质体的种种优点，包括物理稳定性高；防止药物降解，提高药物稳定性；缓释性能好，耐受性强等等。此领域的研究表明，在最佳条件下，SLN可适用于疏水或亲水性药物的传递，从而实现最佳微粒载体系统的要求。本文将综述SLN在基因传递、蛋白多肽类药物非注射给药、难溶性药物增溶及靶向给药系统中的研究和应用。 关键词：固体脂质纳米粒；基因传递；蛋白多肽类药物非注射给药；难溶性药物增溶；靶向给药系统 Studies and applications on Solid lipid nanoparticles LIU Chun-xi1, ZHANG Na1* (1. School of Pharmaceutical Science, Shandong University, Ji’nan 250012, China Abstract Since their first description by Müller et al., solid lipid nanoparticles (SLN) have attracted increasing attention as an efficient and non-toxic alternative lipophilic colloidal drug carrier prepared with common pharmaceutical excipients such as physiological fatty substance or lipid. Solid lipid nanoparticles combine the advantages of polymeric nanoparticles, lipid emulsions and liposomes, such as physical stability, protection of incorporated labile drugs from degradation, controlled release, excellent tolerability and so on, while simultaneously avoiding their disadvantages.The research work developed in the area confirms that under optimized conditions, they can be produced to incorporate hydrophobic or hydrophilic molecules and seem to fulfill the requirements for an optimum particulate carrier system. In this article, the applications of SLN in gene delivery, non-injection system for protein and polypeptide, solubilizaion and targeted drug delivery system will be reviewed. Key words: solid lipid nanoparticles, gene delivery, non-injection system for protein and polypeptide, solubilizaion, targeted drug delivery system 固体脂质纳米粒( solid lipid nanoparticles, SLN) 是新型的亚微粒胶体给药系统，其研究始于20 世纪90 年代[1]。SLN是一种以室温下为固态的天然或合成的脂质或类脂，如卵磷脂、三酰甘油等为基质，将药物包裹于类脂核中制成粒径约为50-1000nm的固体脂质粒子给药体系。SLN主要适合于难溶性药物的包裹，用作静脉注射或局部