基于磁分选技术与光谱技术对于肿瘤细胞的分离及检测-物理化学专业论文.docxVIP

优秀毕业论文 精品参考文献资料 Abstract Abstract Shanghai Normal University Master of Philosophy Abstract Nanotechnology is based modem technology combining modem science with modem technology。This technology is an interdisciplinary to research the properties and applications of material whose partical size is in the range of l nm to 1 00nm．As the special chemistry and physics property，nanomaterial is used in the physical testing and biological applications and SO on．Nanotechnology has high sensitivity and efficiency the testing of substances．Circulating tumor cell(CTC)is small number of tumor cells which exists in peripheral blood．This tumor Can transfer to other organs through blood．The transfer of tumor cells is the main reason to make the death of patients．In the early phase，the diagnosis of circulating tumor cell conduces to identify benign and malignant tumors and transfer risk prediction and assessment． So the early diagnosis and treatment to CTC have important implication to cancer patients．Immunomagnetic separation technology is an immunological technique combining high specificity of immunology with magnetic responsiveness of magnetic beads．This paper is devoted to detect and separate the circulating tumor cells through the magnetic separation technology．The Immunomagnetic and the Raman nanoparticle in this paper have small partical size，uniform dispersion and high specificity．This paper structure the good performance method to capture and detect circulating tumor cells through combining Immunomagnetic separation technology with indirect immunofluorescent technology or surface enhanced Raman scattering technology．The main researches are as follows． 1．Based on the development and application of magnetic separation technology m tlle tumor cell sorting，the circulating tumor cells Can connect with the specific proteins the Immunomagnetic’S surface．The aim cells Can be separated from the mixed cells in th