星点设计-效应面优化眼用银黄温敏凝胶的制备工艺.PDFVIP

国际中医中药杂志2019年1月第41卷第1期 Int J Trad Chin Med, January 2019, Vol. 41, No.1                           ·67 ·  ·实验与方药 · 星点设计-效应面优化眼用银黄温敏 凝胶的制备工艺 1 2 陈智 叶思勇 1 2 山东中医药大学药学院，济南 250355 ； 济南市第二人民医院药剂科 250001 通信作者：陈智，Email:chenzhi6088@163.com，电话：0531 【摘要】 目的 研究眼用银黄温敏凝胶的制备工艺。方法 以泊洛沙姆407 、泊洛沙姆 188 用量为 考察指标，以胶凝温度为考察指标，采用星点设计-效应面法筛选银黄温敏凝胶处方，并对其他辅料因素 进行考察，确定眼用银黄温敏凝胶的最佳制备工艺。结果 眼用银黄温敏凝胶最佳处方为：泊洛沙姆407 用量 20% ，泊洛沙姆 188 用量 1%，透明质酸用量 0.1%，苯扎氯铵用量 0.01%，乙二胺四乙酸用量 0.02% 。 结论 眼用银黄温敏凝胶制备工艺简单，稳定性好，相变温度适宜。 【关键词】 凝胶剂(中药)；星点-设计响应面法；泊洛沙姆；剂型改进 基金项目：山东省自然科学基金(ZR2017LH070)；山东省高等学校科技计划项目(J17KA245) DOI: 10.3760/cma.j.issn.1673-4246.2019.01.016 Optimized the preparation process of thermo-sensitive Yinhuang ophthalimic gel by central composite design-response surface method Chen Zhi1, Ye Siyong2 1College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China; 2Pharmacy Department, the Second Peoples Hospital of Jinan, Jinan 250001, China Corresponding author: Chen Zhi, Email: chenzhi6088@163.com, Tel: 0531 【Abstract 】 Objective To optimize the preparation technology of thermo-reversible Yinhuang opthalimic gel by the central composite design-response surface method. Methods The poloxamer 407 and poloxamer 188 were used as the investigation factors, and the evaluation index was the gel temperature. Central composite design-response surface method was used to evaluate the mathematic relation between the evaluation index and tow investigation indexes to identify the optimum prescription. Results According to the quadratic models, it was found that there was reliable quantitative relation between the evaluation index