内科学系统挣性红斑狼疮於强.ppt

Systemic Lupus  Erythematosus Zhongshan Hospital 於强 What is Lupus a chronic, relapsing, inflammatory,  and often febrile multisystemic disease  of connective tissue, characterized  principally by involvement of the skin.  Joints, kidneys and serosal membranes. an autoimmune disease 一. Types of lupus ▲ Discoid ▲ Systemic ▲ Drug-induced 二. Characteristic of disease: ▲ Atuoimmune ▲ Target tissue damage: connection tissue (shin、Joint、 muscles) ▲ Predominantly population： women during their reproductive year 90% ▲ morbidity：70 per 100，000 三. Pathogenic factor ▲ Susceptibility gene：HLA-DR/DQ ▲ Environmental Factors： a. ultraviolet light b. food high caloris, saturated fat, sprout c. drugs isoniazid, methyldopa D-penicillamine chlorpromazine ▲ Sex hormone ▲ Infections agents 四. pathogenesis with a complex set of immunologic abnormalities that appear to involve multiple mechanisms of dysregulation Susceptibility gene 五. Pathology 1. vasculitis 2. lupus nephritis a. minimal change b. mesangial proliferative c. focal segmental lesions d. diffuse e. membranous f. sclerosing 六.Clinical menifestations  of SLE -----Multiple system