蔡佳-第三军医大学学报.DOC

粪便钙卫蛋白在门诊常见肠道疾病诊断中的作用 蔡佳， 章述军 重庆医科大学附属第一医院感染科 目的：研究粪便钙卫蛋白在诊断常见肠道疾病-IBD、IBS、结肠癌中的作用。 方法：选取门诊病人新鲜粪便共120例，其中健康对照组、IBS组、IBD组及结肠癌组各30例，用ELISA法定量检测各组中粪便钙卫蛋白水平，确定钙卫蛋白诊断IBD及结肠癌的敏感性和特异性，并与传统炎症相关性指标ESR、CRP、WBC相比较。 结果：IBD组与结肠癌组、IBS组、健康对照组比较，粪便钙卫蛋白水平的差异均具有统计学意义（P＜0.05）。而结肠癌组与IBS组、健康组比较，差异也均具有统计学意义（P＜0.05）。粪便钙卫蛋白诊断IBD的敏感性为86.7%，特异性为83.3%。钙卫蛋白诊断结肠癌的敏感性为86.7%，特异性为76.7%。 结论：粪便钙卫蛋白不仅能够较准确地区分肠道器质性疾病和功能性疾病，而且在鉴别IBD和结肠癌方面同样具有一定的价值，是一种值得推广的非侵入性的检查方法。 关键词：粪钙卫蛋白 炎症性肠病 肠易激综合征 结肠癌 The Value of Fecal Calprotectin in the Differential Diagnosis of Common Intestinal Diseases for Out Patients. CAI Jia，Zhang Shujun infectious disease Division, the first affiliated hospital, Chongqing medical University, Chongqing, 400016, China. Aims: To investigate the significance of Fecal calprotectin（FC） in differential diagnosis of common intestinal diseases such as inflammatory bowel disease (IBD), irritable bowel syndrome(IBS) and colon cancer. Methods: A total of 120 fresh fecal samples were collected from the out patients, including 30 cases of each group of IBS, IBD and healthy subjects. ELISA was used to quantitatively determine the level of fecal calprotection of each group, determine the sensitivity and specificity of the calprotectin diagnosis of IBD and colon cancer comparing with traditional inflammation indicators erythrocyte sedimentation rate(ESR), C reactive protein(CRP) and white blood cell count(WBC). Results: The level of FC in IBD group compared with the group of colon cancer, IBS and healthy subjects group, the differences were statistically significant (P 0.05). The level of FC in colon cancer group compared with the IBS and healthy group, the differences were statistically significant as well (P 0.05). The sensitivity of fecal calprotectin diagnosis of IBD is 86.7%, and the specificity is 83.3%, with the sensitivity for colon cancer is 86.7% and the specificity is 83.3%. Conclusion: The fecal calprotectin can not only accurately distingu