聚乳酸-聚乙二醇-聚乳酸义sio,2杂化材料的制备与性能研究.docx

聚乳酸一聚7,--醇一聚乳酸／Si02杂化材料的制备与性能研究 聚乳酸一聚7,--醇一聚乳酸／Si02杂化材料的制备与性能研究 摘 要 论文较深入地研究了聚乳酸一聚乙二醇一聚乳酸(PLA．PEG．PLA)／Si02 杂化材料的制备及杂化材料的性能。 以正硅酸乙酯(TEOS)和PLA．PEG．PLA为原料、采用溶胶凝胶法制 备出PLA．PEG．PLA／Si02杂化材料，并通过FT-IR、XPS、DSC、XRD、SEM 等测试手段对相关产物进行表征。结果显示，Si02与PLA．PEG．PLA基质 间以C．O．Si键结合，相容性良好。与纯PLA．PEG．PLA材料相比， PLA-PEG．PLA／Si02杂化材料仍为无定形聚合物，但是其玻璃化温度有所 提高，并随着硅含量的增加而增高。杂化材料在37℃的生理盐水中的降解 试验结果表明，PLA．PEG．PLA／Si02杂化材料降解12周后，呈三维立体支 架结构，有利于血管及骨细胞黏附长入： 由于Si02的引入，使 PLA-PEG．PLA降解的酸性产物在一定的程度上得到中和，可以减小因 PLA-PEG．PLA酸性过高引发的炎症反应，便于细胞增殖和组织修复。 以自制的PLA．PEG．PLA／Si02材料作为药物载体，通过W／O／W复乳 化溶剂挥发法制备出地塞米松磷酸钠(DSP)．PLA．PEG．PLA／Si02微球，并 对微球的粒径、载药量以及体外缓释性能进行了研究。微球粒径大约在8斗m 左右，载药量为5．72％左右，符合缓释制剂要求。体外缓释研究结果显示 DSP—PLA．PEG．PLA／Si02微球具有明显缓释作用。 关键词：PLA．PEG．PLA／Si02 杂化 降解性能 微球 缓释 Study Study on the Preparation and Degradation of Poly(1actic acid)一Poly(ethylene glyc01)一Poly(1actic acid)／Si02 Hybrid Material Abstract The synthesis and characterization of poly(1actic acid)一poly(ethylene glyc01)一poly(1actic acid)(PLA—PEG—PLA)／Si02 hybrid material was explored in this paper． Using tetraethoxysilane(TEOS)and PLA—PEG-PLA as start material， PLA-PEG·PLA／Si02 hybrid material was synthesized by sol-gel method，and the relative result products were characterized by FT-IR，XPS，DSC，XRD and SEM．The results indicated that Si02 combined with PLA—PEG—PLA by C一0-Si bond． Compare with pure PLA—PEG—PLA material， PLA-·PEG-·PLA／Si02 hybrid material was amorphous alike pure PLA-PEG—PLA，but the glass transition temperature of PLA-PEG—PLA／Si02 hybrid material is higher than that of PLA·-PEG·-PLA and increases with increase of silica content．The in vitro degradation of hybrid materials was conducted in normal saline at 3 7℃．The results showed that after the PLA-PEG-PLA／Si02 hybrid material degraded in saline for 1 2 weeks，a three—dimensional porous scaffold was obtained．This character scaffold is available for the growth of cells and blood vessel．Moreover，the hydroxyl groups on Si02 of the PLA—PEG-PLA／Si02 hybrid material could buffer the acidic degrading p