营养基因组学研究进展.pdf

HEREDITAS (Beijing) 2008 2 , 30(2): 129―134 ISSN 0253-9772 综述 DOI: 10.3724/SP.J.1005.2008.00129 陈琴, 王文君, 上官新晨, 徐明生 , 330045 摘要：营养学是一门古老的学科, 为人们的健康保护和疾病预防提供了重要的理论指导。随着分子生物学技术 的发展, 它已成为 21 世纪生命科学研究最为主要的技术之一。分子生物学与营养学的结合, 产生了分子营养 学。而基因组学与营养学的结合, 则形成了营养基因组学。营养基因组学涵盖了一个广泛的领域, 它研究营养 素和基因表达的相互影响, 预测其对营养素的反应。基因组学技术可以帮助确认一些与疾病发生有关的基因, 人们可以根据各自的基因图谱制定一份个性化的饮食方案, 以此防病治病, 使人们的健康状况通过调整饮食来 达到最佳。文中重点介绍了营养基因组学的主要研究方法及其应用。 ：个人营养食谱; 基因组学; 单核苷酸多态; 营养基因组学 Research progresses on nutrigenomics CHEN Qin, WANG Wen-Jun, SHANGGUAN Xin-Chen, XU Ming-Sheng College of Food Science and Engineering, Jiangxi Agricultural University , Nanchang 330045, China Abstract: Nutrition science is an age-old subject, and offers important theoretic instructions for human health protection and disease prevention. With the development of molecular biology, it will be a key technique in the 21 century. Combina- tion of molecular biology and nutrition, bio-nutrition is formed. While the combination of genome and nutrition, nutrige- nomics is developed. Nutrigenomics covers a wide range of areas, which studies the interactive effects between nutrients and genes expression, and predicts the expressive response to the nutrients. Genomics technology can help us to identify some disease-related genes, thereby people establish individual diet and make their heath attained the best status through adjusting diet. This paper focuses on the main research technology of nutrigenomics and its application. Keywords: individual nutritional diet; genomics; SNP; nutrigenomics 18 , 1900 , , , 3 ·“ , ”