慢性阻塞性肺疾病患者超敏C反应蛋白和纤维蛋白原含量的变化和其临床意义.pdfVIP

Advances in Clinical Medicine 临床医学进展, 2017, 7(5), 265-270 Published Online December 2017 in Hans. /journal/acm /10.12677/acm.2017.75044 The Changes and Their Clinical Significance of Serum High-Sensitivity C-Reactive Protein (hs-CRP) and Plasma Fibrinogen (Fib) in COPD Patients Hongli Wu, Ruixue Tian, Qing Ye, Yujia Song Department of Respiratory Medicine, Haidian Hospital, Beijing th rd th Received: Nov. 13 , 2017; accepted: Nov. 23 , 2017; published: Nov. 30 , 2017 Abstract Objective: To investigate the changes of serum high-sensitivity C-reactive protein (hs-CRP) and plasma Fibrinogen (Fib) in patients with acute exacerbation of chronic obstructive pulmonary dis- ease (COPD). Method: A case control study was carried out on 80 cases of the AECOPD patients ad- mitted Respiratory Medicine of our hospital since December 2015 to December 2016. Forty five AECOPD patients (AECOPD group), thirty five patients with COPD at stable phase (SCOPD group), se- venty five healthy people (control group) were selected in this study. And their hs-CRP and plasma Fib in serum were tested, the differences in three groups were compared. Meanwhile, their FEV1%pred and FEV1/FVC(%) also be measured. Results: The level of hs-CRP and Fib in AECOPD group, SCOPD group, control group were [(15.23 ± 7.01) mg/L, (4.79 ± 1.31) g/L], [(3.61 ± 2.84) mg/L, (3.87 ± 1.63) g/L], [(1.76 ± 1.25) mg/L (3.03 ± 0.44) g/L]. The level of serum hs-CRP and Fib were significantly increased in patients with AECOPD as compared with controls and stable COPD (p 0.05). Comparison between stable COPD and control group about serum levels of hs-CRP and Fib had significant