纤维肌痛症相关性睡眠障碍探究进展.pdfVIP

中国临床神经科学 2012年第 20卷第3期 Chin J Clin Neurosci 2012,20 (3),329~334 32 9 进 展 纤维肌痛症相关性睡眠障碍的研究进展 沈红健，赵忠新，黄流清 (第二军医大学附属长征医院神经内科 200003) 关键词 纤维肌痛症； 睡眠障碍； 非恢复性睡眠； a 波侵入 摘要 纤维肌痛症是一种以弥漫性疼痛和肌肉骨骼压痛为特征的慢性疼痛综合征。睡眠障碍是主要的临床表现之一， 其中非恢复性睡眠和- 睡眠是纤维肌痛症重要的两个标志。美国风湿病学会20 10 年修订的诊断标准中也将睡眠障碍 提升到诊断依据的高度。本文主要介绍纤维肌痛症相关性睡眠障碍临床表现、多导睡眠图和循环交替模式的特点、主 观和客观评定方法、治疗方面的研究进展。 The Advance on Studies of Fibromyalgia-related Sleep Problems SHEN Hong-J ian, ZHA O Zhong-X in, H UAN G Liu-Qing Department of Neurology, Changzheng Hospital, the Second Military Medical University, Shanghai 200003, China KEY WORDS fibromyalgia; sleep disturbances; non-restorative sleep; alpha-wave intrusion ABSTRACT Fibromyalgia syndrome is a chronic pain disorder clinically characterized by widespread pain and musculoskeletal tenderness. Disturbed sleep is a maj or symptom of patients with fibromyalgia. Non- restorative sleep and alpha/delta sleep have been proposed as the two important hallmarks. The newest revised diagnostic criteria proposed by the American College of Rheumatology also suggested that the presence of sleep disturbances be part of the diagnostics for fibromyalgia in 2010. The clinical features, the characteristic of polysomnography and cyclic alternating pattern, the assessment of subj ect and obj ective sleep, therapy of fibromyalgia-related sleep problems were reviewed. 纤维肌痛症(fibromyalgia)是慢性疼痛综合征中最难 纤维肌痛症概述 治疗的疾病之一，多数纤维肌痛症患者被各种睡眠问题 所困扰。目前认为纤维肌痛症相关性睡眠障碍与神经内 纤维肌痛症是一种以弥漫性对称性肌肉骨骼疼痛、 分泌、免疫功能异常以及疼痛、疲劳、情绪障碍等相伴 特殊部位压痛为特征，可伴有睡眠障碍、焦虑、抑郁、疲 症状的严重程度紧密相关，提高睡眠质量可以缓解疼 劳感、晨僵、头痛、肠应激综合征等表现的综合征。流 痛、疲劳、焦虑等症状，但目前针对睡眠障碍的有效治 [2~ 6]