一种新型兽药载体———淀粉微球的制备及其特性-河南农业科学.PDF

DOI :10.15933/j.cnki .1004 -3268.2008.02.032 河南农业科学 ——— 沈小玲, 孙庆元, 蒙　敏,朱　强 ( , 116034) 5 :以可溶性淀粉为原料,环氧氯丙烷为交联剂,用乳化交联法制备淀粉微球,采用L 16 (4 )正交 设计筛选 最佳制备条件, 对微球形态、粒径分布进行观察;用吸附载药法制备阿司匹林淀粉微球, 对载药量、包封率和体外释药性能进行了研究。所得微球形态圆整,平均粒径为38.75 μm, 粒径分 布在20 ～60 μm, 载药量为8.38%, 包封率为84.2 %, 体外释放符合一级动力学方程, 并具有明显 的缓释作用。 :阿司匹林;淀粉微球;兽药;缓释 :S859 　　:A 　　:1004-3268 (2008)02-0111-04 P reparation of A New M edicine Carrier ———Starch Micro phere and It Relea ing Su tainability for Live tock S HEN Xiao-ling, SUN Qing-y uan, M ENG M in, ZH U Qiang (College of Biology and Fo od Engineering, Dalian P olytechnic Univ er ity, Dalian 116034, China) Abstract:The tarch micro phere w ere prepared through emul if ied cro -linking of oluble 5 tarch and epichlorohydrin.The L16 (4 )or thogo nal ex periment w ere carried out to conf irm the optimal co ndition of preparatio n.The morpholo gy and partical ize of micro phere were ob- erved.The a pirin w a ad orbed in the m icro phere , and then the drug loading rate, em bedding rate and di olution in vi tro w ere tudied .The micro phere w ere pherical w ith average ize of 38.75μm,loading capacity of 8.38%and entrapment rate of 84.2%.The partical ize ranged from 20 to 60 μm,an optimal value for na al admini tratio n.A pirin w a relea ed from the micro phere in a u tained manner,w hich comformed to the fir t-order kinetic equation . Key words:A pirin;Strach micro phere;A nimal drug ;Su tained relea e [3] 　　, ,, 。 ; 、, , ,, , , 。 。 , 、 ,、、 , , , FDA [1] [4] 。, , [2] 。