h5亚型流感病毒血凝素与宿主范围局限性相关功能区识别与分析预防兽医学专业论文.docxVIP

Thr、Tyr等促结合氨基酸突变时；尤其是这些位点突变为Tyr、Arg、Asn、Lys、 Thr、Tyr等促结合氨基酸突变时；尤其是这些位点突变为Tyr、Arg、Asn、Lys、 Ser、Gin等低结合能或易形成氢键的氨基酸时，血凝素仅单个位点变化就可显著 提高与a．2，6唾液酸分子的结合能和氢键数量。推测这些变化可使H5N1亚型禽流感 病毒对人类感染能力提高。 关键词：禽流感病毒；H5N1：受体结合位点；同源建模；动力学模拟；分子对接 Identification Identification and Analysis of Host-range Restriction Related Function Domains on Hemagglutinin of H5 Influenza Viruses ^bstract Since their reemergence in 2003，highly pathogenic avian influenza A(HSNI) viruses have reached epidemic levels among poultry in world and have caused a still increasing number of more than 378 reported human infections and 238 deaths