粪便脱落细胞学和外周血标志物筛查结直肠癌的研究内科学消化系病专业论文.docxVIP

第三军医大学硕士学位论文L-DNA 第三军医大学硕士学位论文 L-DNA long DNA 长片段DNA ELISA Enzyme-linked immunosorbent assay 酶联免疫吸附法 ．MGMT．一0-6-methylguanine-DNA 甲基鸟嘌呤甲基转移酶 methyltransferase MSI microsatellite instability 微卫星不稳定性 NDRG4 N—myc downstream regulated gene 4 N—myc下游调节基因4 OSMR oncostatin M receptor 肿瘤抑制素受体 SFRP2 secreted frizzled-related protein 2 分泌型卷曲相关蛋白2 TFPl2 tissue factor pathway inhibitor 2 组织因子通道抑制剂 sDNA stool DNA 粪便去氧核醣核酸检查 FS flexible sigmoidoscopy 乙状结肠镜检查 CTC CT colonography 电脑断层虚拟大肠镜 CE capsule endoscopy 胶囊内视镜 mln Minute 分钟 h Hour 小时 mmol Millimole 毫摩尔 mm Millimeter 毫米 L Liter 升 ml Milliliter 毫升 Ul Microliter 微升 nmol Millimicromole 纳摩 ng Nanogram 纳克 2 万方数据 第三军医大学硕士学位论文Screening 第三军医大学硕士学位论文 Screening of colorectal cancer by fecal shedding cells and peripheral blood markers Abstact Background Colorectal cancer is one of the common malignant tumors in the world，and its incidence rate and mortality rate are the third of all the malignant tumors．In recent years， the incidence of colorectal cancer increased year by year,which has become a threat to public health and life safety of major diseases．Studies show that early effective screening and treatment can reduce the incidence and mortality of colorectal cancer．Currently,fecal occult blood test(FOBT)and Colonoscopy are the most widely used metholds for detection of colorectal cancer．Fecal occult blood test is commonly used，but its sensitivity and specificity are relatively low,and the false negative rate and false positive rate were higher． Although the colonoscopy is a gold standard for clinical screening and diagnosis，but its cost is also high，and can not be promoted as a first—line screening method． Stool detection which is simple，high specificity,noninvasive，and without special detection before preparation，can be used as an important tool for early screening and diagnosis of colorectal cancer．However,there are a lot of impurities such as bacteria，food residue，bile and intestinal mucus in the feces，which leads to the low p