有机钨金属路易士酸的合成及其催化反应活性之探中正大学化学研究所.ppt

Interactive Characteristic between Materials and Microwave Conductor (Metal Material) Reflective Insulator (Telflon) Transparent Dielectric Materials (Water) Absorptive Mechanism of Microwave Heating Dipole Rotation Ionic Conduction Microwave Flash Heating Microwave energy Liquid raises temperature quickly Digestion bottle Organomolybdenum Lewis Acid Catalyzed Mukaiyama Aldol Reactions under Microwave Irradiation Conditions Seddon, K. R. et. al. Pure Appl. Chem. 2000, 72, 2275–2287 Ionic Liquids 10 77 70 10 6 84 69 69 10 5 70 66 10 10 4 55 76 81 10 3 85 67 99 10 2 86 81 64 10 1 Entry R R Time Yield (%) (min) CH3CN DMF BmimPF6 10 72 70 10 12 84 80 73 10 11 65 71 66 10 10 10 95 34 10 9 78 85 72 10 8 85 88 24 10 7 Entry R R Time Yield (%) (min) CH3CN DMF BmimPF6 70 60 12 70 89 6 73 56 11 69 80 5 66 36 10 10 87 4 34 77 9 81 99 3 72 99 8 99 92 2 24 43 7 64 93 1 Yield (%) Thermal mw (5hr) (10mim) R R Entry Yield(%) Thermal mw (5hr) (10mim) R R Entry * * Microwave Assisted Organomolybdenum Lewis Acid Catalyzed Mukaiyama Aldol Reactions Student : Wanchen Lee Supervisor : Prof. Shuchun Joyce Yu 2005 / 07 / 28 Department of Chemistry Biochemistry Chung Cheng University Mukaiyama Reaction Silyl enol ether Ketone or Aldehyde Mukaiyama, T. et. al. Chem. Lett. 1973, 1011-1014 Lewis Acid Catalyzed Mukaiyama Reactions I. Traditional Lewis Acids BF3O(Et)2、AlCl3、InCl3、SnCl4、TiCl4、FeCl3、ZSM-5 II. Organometallic Lewis Acids a. Early Transition Metals: Sc (III)、V(IV)、W(0) Chen, C.T. et. al. Synlett. 1999, 816-818 Loh, T. P. et. al. Chem. C