女性不孕症患者生殖免疫抗体检测结果分析.docx

女性不孕症患者生殖免疫抗体检测结果分析 　　【摘要】目的：分析女性不孕症患者生殖免疫抗体检测情况，为不孕患者的诊疗方案提供参考。方法：选取在我院不孕不育科和妇产科就诊的不孕女性患者2856例，采用酶联免疫吸附法检测各项生殖免疫抗体指标。结果：原发不孕组共442例患者生殖免疫抗体阳性，继发不孕组共594例患者生殖免疫抗体阳性。继发不孕患者生殖免疫抗体阳性率明显高于原发不孕组。两组生殖免疫抗体阳性患者中，以单抗体阳性为主。两组抗体分布统计学检验无显著差异。结论：生殖免疫抗体阳性是影响不孕的原因之一，其中以单阳性抗体为主，且继发不孕患者阳性率高于原发不孕。　　【关键词】不孕症；生殖免疫抗体；原发不孕；继发不孕　　Analysis of the reproductive immune antibody test results of female infertile patientsLI Song1， HE Xuesu2. Laboratory， Dazhou Integrated Traditional Chinese and Western Medicine Hospital， Dazhou ， Sichuan， China.； of Obstetrics and Gynecology， Dazhou Integrated Traditional Chinese and Western Medicine Hospital， Dazhou ， Sichuan， China　　【Abstract】Objectives： To analyze the reproductive immune antibody detection results of female infertile patients， in order to provide reference for the treatment. Methods： 2856 female infertile patients in our hospital were selected and the reproductive immune antibody indicators were detected with enzyme-linked immunosorbent assay . Results： There were 442 cases and 594 cases of positive antibodies in the primary infertility group and secondary infertility group respectively， with statistically significant difference . In patients with positive antibody， the majority was single antibody positive ， without statistically significant difference between the two groups . Conclusions： Positive reproductive immunology antibody is one of the causes of infertility， the majority of which is single positive antibody， and the positive rate in patients with secondary infertility is higher than those of primary infertility.　　【Key words】Infertility； Reproductive immune antibody； Primary infertility； Secondary infertility　　【中图分类号】【文献标志码】A　　据最近研究调查显示，发展中国家不孕不育的发病率是发展中国家的4倍左右，且呈逐渐升高态势[1]。不孕不育不仅影响女性个人身心健康，更对家庭影响颇深，因此，不孕不育已逐渐成为一种社会问题，不容忽视。导致不孕不育的原因有很多，从受精角度分析，精子活性、受精卵形成、着床等一系列过程中出现问题均有可能导致不孕不育的发生[2]。研究表明，生殖免疫抗体在上述提及的每个过程中均可能产生影响，干预正常孕育的生理过程，引发不孕不育[3]。在本次研究中，选取XX年1月至XX年6月在我院不孕不育科和妇产科就诊的不孕女性患者2856例，分析女性不孕症患者生殖免疫抗体检测情况，为不孕患者的诊疗方案提供参考。　　1资料与方法