组织预应力和Rho信号与肌原纤维细胞分化的关系.PDF

生物技术通报 BIO TE CHN OLOG Y B ULLETIN 2009 4 Rho 黄岂平 方咸平 (, 400044) : 肌原纤维细胞(myofibroblast)在愈伤反应(woundhealing response) 中扮演十分重要角色而当机体组织 损 时, 组织内预应力环境将被破坏, 出现不同程度的应力集中和应力松弛,从而影响细胞骨架张力, 而骨架张力可以转化为细胞 信号事件, 针对组织预应力和 Rho信号与肌原纤维细胞分化之间的关系进行探讨 : 肌原纤维细胞 组织预应力 骨架张力 Rho信号通路 R esearch on R elations between the Prestressed and Rho Signal w ith M yofibroblast D ifferentiation Huang Q iping Fang ianping (B ioeng ineering Colleg e, Chong qing Un iv ersity, Ch ongq ing 400044) Abstrac:t M yofibroblast plays an mi portant role in woundhealing responseW hen organism tissue injured, the prestressed envi ronmentwould be destroyed bywhich stress concentration and stress relaxationwould appear thatwould affect cell skeleton tensity, but the skeleton tensity can be transformed as cell signal eventThis article discussed the relations of the prestressed and the Rho signal w ithM yofibroblast differentiation K ey w ords: M yofibroblast Prestressed in tissue Skeleton tensity Rho signal (myofibroblast, MFb) , , ( woundhealing re RhoA [9] sponse), , ,, , , ,, 1 , ,, , , [ 1~ 3] , , (SM , actin),, , , ( vmi entin), [ 1, 4~ 6] , SMactin ( ECM ) I! ( fibronectin, [7, 8] , FN) ECM ,, ,ECM ,