前列腺素F2α受体与原发性痛经关系-现代仪器与医疗.PDFVIP

经验交流 2016年  第22卷   第2期 前列腺素F 受体与原发性痛经关系 2α 寇小平　邵莹　卢占斌 （西安交通大学医学院附属医院西安高新医院妇科，西安　710057 ） [摘　要]　目的：检测原发性痛经患者外周血中前列腺素F2 α 受体的变化及临床意义。方法：选取 2014 年3 月至2015 年9 月期间，来本科就诊的60 例原发性痛经患者作为实验组，选取同期来本院体 检的 60 例健康月经期女性作为对照组。利用Elisa 法检测实验组与对照组前列腺素F2 α 受体变化。将 60 例原发性痛经患者随机分为A 组30 例和 B 组30 例，A 组口服前列腺素抑制剂（萘普生片）治疗， B 组口服元胡止痛片治疗，观察2 组治疗后临床疗效，治疗前后外周血前列腺素F2 α受体变化情况。结果： 与对照组相比，在经期来潮2 天，实验组前列腺素F2 α 受体浓度明显升高。对比A 组治愈率明显高于 B 组。完成规定疗程后A 组前列腺素F2 α 受体浓度明显降低。结论：前列腺素F2 α 受体与原发性痛经 发病机制密切相关，抑制其表达，可以有效治疗原发性痛经。 [关键词]　原发性痛经；前列腺素F2 α 受体；Elisa 中图分类号：R711　文献标识码：A　文章编号：2095-5200(2016)02-110-03 DOI：10.11876/mimt201602043 Relationships between prostaglandin F α receptors and primary dysmenorrhea　KOU 2 Xiaoping SHAO Ying LU Zhanbin. Department of gynaecology ,Xi’an Gaoxin hospital, Xian ， ， （ 710057,China ） [Abstract]　Objective: To detect the changes and clinical significance in prostaglandin F2α receptors in patients with primary dysmenorrhea. Methods: 60 cases of patients with primary dysmenorrhea underwent treatment in our department were selected as the experimental group, the 60 females with healthy menstrual period who went for physical examination were selected as a control group from March 2014 to September 2015. Prostaglandin F2α receptors changes of experimental group and control group were detected by Elisa assay. 60 patients with primary dysmenorrhea were randomly divided into group A (30 cases) and group B (30 cases), group A was treated with prostaglandin inhibitors (naproxen tablets) therapy; group B took Yuanhu tablets for alleviating pain orally in the treatment. The clinical efficacy of two groups after treatment, and prostaglandin F2α receptor changes of peripheral blood before and after treatment were observed. Results: Compared with the control group, during two days of menstru