医学免疫学第二十五章 肿瘤免疫.pptVIP

a?| Natural killer (NK) cells are tolerant to healthy host cells, as the strength of the activating signals they receive on encountering these cells is dampened by the engagement of inhibitory receptors (tolerance).?b?| Tumour cells may lose expression of MHC class I molecules. NK cells become activated in response to these cells, as they are no longer held in check by the inhibitory signal delivered by MHC class I molecule engagement. This is known as missing-self triggering of NK cell activation.?c?| In addition, NK cells are selectively activated by stressed cells, which upregulate activati