核磁共振法在苷键构型确定中的应用Applicationofnuclear-药学学报.PDF

药学学报 Acta Pharmaceutica Sinica 20 11, 46 (2) : 127 131 ·127 · 核磁共振法在苷键构型确定中的应用 * 裴月湖, 华会明, 李占林, 陈 刚 (沈阳 科大学中药学院, 辽宁 沈阳 110016) 摘要: 天然苷类化合物结构测定过程中核磁共振是测定苷键构型的重要方法。利用端基质子的偶合常数和 13 端基碳的化学位移值判断苷键构型是最常用的方法, 但有些糖不适用这种方法, 而需要借助 C NMR 谱数据分 1 13 析确定苷键构型。本文通过归纳文献数据, 总结利用 H NMR 和 C NMR 谱的特征判断各种常见单糖苷键构型 的方法。 关键词: 核磁共振; 糖苷键; 构型 中图分类号: R914 文献标识码:A 文章编号: 05 13-4870 (20 11) 02-0127-05 Application of nuclear magnetic resonance to the determination of the configuration of glycoside bond * PEI Yue-hu, HUA Hui-ming , LI Zhan-lin, CHEN Gang (School of Traditional Chinese Materia Medica, Sheny ang Pharmaceutical University, Sheny ang 110016, China) Abstract: In the structural determination of natural glycosides, nuclear magnetic resonance (NMR) is an important approach in determining the configuration of glycoside bond. The test of coupling constant of the anomeric proton and chemical shift of the anomeric carbon are two common methods, but these methods are not suitable for some sugars. For those sugars, detailed 13C NMR analysis is an alternative choice. This paper summarizes the characteristics of 1H and 13C NMR data of the common monosaccharides published in the literatures, in order to search an approach to determine the co