复方苦参注射液联合化疗对乳腺癌免疫功能影响的Meta分析.DOC

ADDIN CNKISM.UserStyle复方苦参注射液联合化疗对乳腺癌患者免疫功能影响的Meta分析* 付芳梅1 罗时辉1 王鹰1 章跃平1 徐安1 庄莹1 孟洁1 李佳玮2 （1江西省中西医结合医院肿瘤科 南昌330006；2南昌大学第二临床医学院 江西南昌330004） 摘要：目的：系统评价复方苦参注射液联合化疗对乳腺癌患者免疫功能的影响。方法：计算机检索PubMed、Embase、Cochrane Library、VIP、WanFang Data、CNKI和CBM，查找国内外已发表的复方苦参注射液联合化疗对乳腺癌患者化疗后免疫功能的影响的随机对照研究（RCT）。在由2位研究者根据制定的纳入与排除标准筛选文献、提取资料和评价文献质量后，利用RevMan 5.3软件进行Meta分析。结果：最终纳入9项研究，共655例患者。Meta分析结果显示：与单纯化疗相比，复方苦参注射液联合化疗能提高乳腺癌患者的CD4+[SMD=5.36，95%CI（2.03，4.37），P0.00001]及CD8+[SMD=4.88，95%CI=（2.40，5.62），P0.00001]，CD4+/CD8+[SMD=4.58，95%CI=（1.04，2.59），P0.00001]。结论：复方苦参注射液联合化疗能显著提高乳腺癌患者的免疫功能，但由于纳入研究的文献数量及质量有限，本Meta分析的结论仍需更多大样本、设计合理的RCT加以验证。 关键词：乳腺癌；复方苦参注射液；化疗；免疫功能；Meta分析 Meta-analysis the Effect of Fufangkushen Injection Combined with Chemotherapy on Immune Function in Patients with Breast Cancer FU Fang-mei1, LUO Shi-hui1, WANG Ying1, ZHANG Yue-ping1, XU An1, ZHUANG Ying1, MENG Jie1, LI Jia-wei2 (1The Department of Oncology, the Jiangxi Hospital of Integrated TCM WM, Nanchang330003; 2The Second Clinical College of Nanchang University, Nanchang330004) Abstract: Objection: To systematically evaluate the effect of the Fufangkushen injection combined with chemotherapy on immune function in the treatment of breast cancer. Method: Through searching the Pubmed, CNKI, VIP, Wangfang Data, CBM, recruited randomized controlled trials (RCTs) related to the immune impact of Fufangkushen injection combined with chemotherapy treatment breast cancer. The quality of included studies was assessed by 2 independent researchers according to the criteria recommended by the Cochrane Collaborations interventions and Meta analyses was conducted using RevMan5.3 software. Result: 8 Randomized controlled trials involving 551 patients were included in the study. The result of Meta analysis showed: the immune parameters of Fufangkushen injection combined with chemotherapy group, such as CD4+, CD8+, CD4+/CD8+, were significantly higher than chemotherapy group. Its SMD and 95%CI were CD4+ [SMD=5.36,