银杏叶聚戊烯醇联合化疗肿瘤的药效研究-林产化学与工业.PDF

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银杏叶聚戊烯醇联合化疗肿瘤的药效研究-林产化学与工业.PDF

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银杏叶聚戊烯醇联合化疗肿瘤的药效研究-林产化学与工业

23 3 Vol. 23 No. 3 2003 9 Chemistry and Industry of Forest Products Sept. 2003 1 1 2 王成章 , 沈兆邦 , 高凌 ( 1. 中国林业科学研究院林产化学工业研究所, 江苏南京210042; 2. 江苏省肿瘤防治研究所, 江苏南京210009) WANG C Z : ( GP) S180, (ADM) ( 5-Fu) ( CTX) (PDD) , S180 , ADM 5-FuCTX PDD , CTXPDD5-Fu , S18059. 81% 43.06% 42. 03% 0. 56% 60. 29% 63.45% ; ADM , 1.0 mg/ kg ADM S18050. 93% . 19% , : ; ; ; S180 : S 92. 95; R 30. 53 :A :0253- 241 (2003) 03- 0015- 04 PHARMACOLOGY OF POLYPRENOLS FROM GINK GO BIL OBA L. LEAVES IN COMBINATION WITH CHEMOTHERAPEUT IC DRUGS ON TUMOR 1 1 2 WANG Cheng-zhang , SHEN Zhao-bang , GAO ling ( 1. Institute of Chemical Industry of Forest Products, CA F, Nanj in 210042, China; 2. Jian su I nstitute of Prophy lactic and Therap eutic T umor , N anj in 210009, China) Abstract: Pharmacology of polyprenols from Gink o biloba L. leaves( GP) in combination w ith chemotherapeutic drugs on tumor was studied. Polyprenols separated and purified from G. biloba L. leaves were administered in combination w ith adriamycin(ADM) , 5-flauouracil( 5-Fu) , cyclophosphamide( CTX) and cisplatin(PDD) respectively, in contrasting wit h ADM, 5-Fu, CTX and PDD alone. Experiments were carried out on mouse with transplanted S180. Results show that for polyprenols in combination w ith CTX, PDD and 5-Fu, the inhibition of S180 nodule was raised from 59. 81% , 43. 06% and 42. 03% to 0. 56% , 60. 29% and 63. 45% respectively, in contrasting wi