肥厚型心肌病心肌MRI延迟强化的研究进展-解放军医学杂志.PDFVIP

704　 解放军医学杂志　2018年8月1 日　第43卷　第8期 肥厚型心肌病心肌MRI延迟强化的研究进展 陶阳，褚志刚 [摘要]　肥厚型心肌病(HCM)是一种常见的遗传性心血管疾病，是年轻人心源性猝死的首要原因。心肌纤维化在 HCM 的发生、发展中发挥着重要作用，而心脏磁共振心肌延迟强化(LGE)与心肌纤维化之间具有良好的相关性。如何 通过LGE准确评价心肌纤维化程度、有效识别高危患者，具有十分重要的临床意义。本文通过复习国内外有关HCM 的 研究，对HCM 中LGE 的表现特点、发生和发展、定量评价及其与心肌功能、心电图异常和预后等方面关系的研究进展 进行综述。 [关键词]　心肌病，肥厚性；延迟强化；磁共振成像 [中图分类号]　R542.2　　　　[文献标志码]　A　　　　[文章编号]　0577-7402(2018)08-0704-06 [DOI]　10.11855/j.issn.0577-7402.2018.08.15 Research progress of delayed-enhancement on cardiac MRI in patients with hypertrophic cardiomyopathy * TAO Yang, CHU Zhi-gang Department of Radiology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China * Corresponding author, E-mail: chuzg0815@163.com This work was supported by the National Natural Science Foundation of China , and Chongqing National Health and Family Planning Commission Project (2016MSXM018) [Abstract]　Hypertrophic cardiomyopathy (HCM) is a common hereditary cardiovascular disease and the leading cause of sudden cardiac death in young people. Previous studies have shown that myocardial fibrosis plays an important role in the development and progression of HCM, and there was a good correlation between myocardial late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging and myocardial fibrosis. How to accurately evaluate the degree of myocardial fibrosis by LGE and effectively identify high-risk patients is of great significance. The characteristic, development and progression, quantitative evaluation of LGE and correlations between LGE and myocardial function, ECG abnormality and prognosis are herewith summarized in present paper by reviewing recent researches on HCM. [Key words]　cardiomyopathy, hypertrophic; delayed enhancement; magnetic res