基于多模板分子印迹聚合物电化学传感器的研究-分析化学专业论文.docxVIP

摘要传感器。当响应时间为7 摘要 传感器。当响应时间为7 min时，MIPs传感器对SA浓度响应的线性范围为1．0x10巧～ 3．6x104 mol／L，检出限(S／N=3)为5．0x10西mol／L，SA响应值的RSD为2．4％(n-5)， 同一支MIPs传感器对PP浓度响应的线性范围为1．0x10弓～1．2×104 mol／L，检出限 (S／N=3)为1．0x10一mol／L，PP响应值的RSD为2．6％(n--4)。该分子印迹膜传感器对 实际化妆品样品进行分析，加标回收率在99．2---104．8％之间。 基于混合模板分子印迹技术的传感器，调节模板分子的比例，既可以实现同系物总 量的测定，又可以进行不同类别化合物的同时测定。且制作简单，操作方便，并具有一 定的灵敏度和选择性以及良好的重现性。本文为混合模板的分子印迹技术做了有益的尝 试。 关键词：分子印迹聚合物膜；电化学传感器：双模板；尼泊金酯类；水杨酸；方波伏安 法 Ⅱ AbstractAbstract Abstract Abstract Molecularly imprinted polymers(MIPs)are made by synthesizing highly crosslinked polymers in the presence of“imprint”molecules(the template)．After removal of the template。 the polymer call be used嬲a selective binding medium for the print molecule or other structurally analogues．In general，one kind of molecule is imprinted in MIPs to obtain hi曲 selectivity only to the template compound itself．Nevertheless．cross．selectivity is also useful for particular applications．Owing to cross-selectivity，MIPs，using dummy template谢th similar molecular structure to the target molecules，still have molecular recognition ability for target molecule．Additionally，another strategy is to obtain group selectivity by multi—templates imprinted polymer．In the present work，it was attempted to gain similar responses for all four kinds of parabens on the MIPs sensor based on multi·templates imprinted polymer．Accordingly，it is possible to determine the total contents of paraben rapidly in actual samples嘶m the dual—templates MIPs sensor．On the other hand， multi-templates imprinted polymer has potential to detect analytes、析tll nonanalogous structures simultaneously，as these target molecules imprinted in the polymer membrane．The main contents are listed懿follows： In the first part，a selective，sensitive，rapid and reliable method based on molecularly imprinted polymers(MIPs)诵tll dual templates to determine total content of parabens in cosmetics was developed．Wim methylparaben(MP)and propylparaben(PP)as dual-templates，methaerylic acid(MaA)as a function