间充质干细胞抑制肿瘤细胞增殖机制的研究进展-中国细胞生物学学报.PDF

网络出版时间：2014-12-01 18:55 网络出版地址：/kcms/doi/10.11844/cjcb.2014.12.0200.html 中国细胞生物学学报 Chinese Journal of Cell Biology 2014, 36(12): DOI: 10.11844/cj cb.2014.12.0200 间充质干细胞抑制肿瘤细胞增殖机制的研究进展 * 张婧思 侯玲玲 胡红刚 晏 琼 (北京交通大学理学院生命科学与生物工程研究院, 北京100044) 摘要 间充质干细胞(mesenchymal stem cells, MSCs)是能够从多种组织来源的基质细胞分离 出来的一种具有分化潜能的干细胞, 能够分化为脂肪、成骨和软骨细胞等多种组织细胞。研究表明, MSCs对肿瘤细胞具有抑制作用, 其作用机制体现在两方面: 一方面是通过直接分泌蛋白和微泡来 调节肿瘤细胞信号通路和生长所需的因子的表达; 另一方面是MSCs作为肿瘤靶向药物运输载体, 向肿瘤组织输送多种能够抑制肿瘤生长、促进肿瘤细胞凋亡的多种基因或药物。该文针对MSCs 对肿瘤细胞的直接和间接抑制机制进行了综述。 关键词 间充质干细胞; 肿瘤细胞; 抑制机制 Advances in the Inhibitory Mechanism of Mesenchymal Stem Cells on Tumor Cells Proliferation Zhang Jingsi, Hou Lingling*, Hu Honggang, Yan Qiong (College of Life Science and Bioengineering, Beijing Jiaotong University, Beijing 100044, China) Abstract Mesenchymal stem cells (MSCs) which can be obtained from a variety of tissues possess a multiple- differentiation potential towards osteoblasts, adipocyte, chondrocytes and other cells. Precious studies have reported that MSCs can inhibit tumor cells proliferation by two means. At first, MSCs-derived exosomes and cytokines directly reprogram the signaling pathway and regulate the expression of growth factors. Secondly, engineered MSCs can deliver multiple agents and suicide genes straightly into the tumor tissues. Here, we reviewed the direct and indirect inhibitory mechanism of MSCs on growth and progression of tumor cells. Key words mesenchymal stem cells; tumor cells; in