甲状腺激素对冠心病心气虚证患者血浆的变化及意义-中医诊断学专业论文.docxVIP

中文摘要目的：通过测定冠心痛心气虚证患者血浆甲状腺激素(Thyroid 中文摘要 目的：通过测定冠心痛心气虚证患者血浆甲状腺激素(Thyroid hormones，TH)及相关指标儿荼酚胺(CA)水平，并研究血TH水平 与心功能级别的相关关系，以探讨TH指标的变化在中医辨证客观化 研究中的意义。 方法：(1)采用放射免疫分析测定技术(RIA)检测冠心病心气 虚证患者外周血甲状腺激素水平(T3、T4、rT3、TSH)，并与冠心病非 心气虚证组及正常对照组进行比较。(2)运用临床观察法分析冠心 病心气虚证患者的不同心功能级别，并探讨TH变化与心功能级别的 相关关系。(3)运用荧光分光光度法测定冠心病心气虚证患者血浆 儿荼酚胺(NE、E)水平，并与冠心病心气虚证组及正常对照组进行 比较。 结果：(1)冠心病心气虚证组与非心气虚证组及正常组比较，外 周血T3显著降低(P0．05)，rT3显著升高(Po．05)，T4虽较后两组低， 但无统计学意义。非心气虚组和正常对照组比较，各项指标均无显著 差异(P0．05)。(2)随心功能级别的降低，冠心病心气虚证组患者 T3、T4均逐渐降低，二者与心功能级别呈显著正相关(P0．01)：而 rT3逐渐升高，与心功能级别呈显著负相关(P0．01)；TSH随心功能 级别变化无相关性(P0．05)。(3)冠心病心气虚证组与非心气虚证 组及正常人组比较，血浆去甲肾上腺素(NE)、肾上腺素(E)均显 著升高(P0．05)。 结论：(1)冠心病心气虚证患者伴有甲状腺激素的变化，且主要 结论：(1)冠心病心气虚证患者伴有甲状腺激素的变化，且主要 表现为低T3综合征。(2)冠心病心气虚证患者甲状腺激素的改变程 度与心功能状态具有相关性。(3)冠心病心气虚证患者伴有儿荼酚 胺的改变，可反映甲状腺激素的变化。 关键词：冠心病心气虚证 甲状腺激素 低T3综合征 心功能级别 儿茶酚胺 去甲肾上腺素 肾上腺素 Changes Changes and Significance of Plasma Thyroid Hormones in Patients with Coronary Heart Disease with the Heart-Qi Dificiency Syndrome Abstract AIM：In order to explore the changing mle of plasma thyroid hormones in patients with coronary heart disease with the Heart—Qi Dificiency Syndrome(HQDS)and clinical significance of the changes，we measured the level of thyroid hormones and catechotamine in patients with coronary heart disease with HQDS．We also studied the relationship between the level ofthyroid hormones and the cardiac function METHODS：(1)Plasma thyroid hormones level of patients with HQDS were measured with radioimmunoassy and were compared with that of N—HQDS group as well as normal control group．(2)To study the relationship between hormones level and cardiac function，we compared the thyroid hormones level of vary grades of cardiac function．(3)Plasma catecholamine(CA)level of patients with coronary heart disease with HQDS was measured in plasma． RESULTS：(1)T3 was significantly lower in patients with coronary heart disease with HQDS in comparison with N—HQDS group and normal group(p0．05)，while rT3 was significantly higher(p0．05)，while T4 was wa