甲状腺疾病与尿碘的关系探讨-内科学(内分泌与代谢病学)专业论文.docxVIP

新疆医科大学硕士学位论文 新疆医科大学硕士学位论文 PAGE PAGE 1 甲状腺疾病与尿碘的关系探讨 研究生：韩媛媛 导师：樊勇副教授 摘 要 目的：探讨甲状腺疾病与尿碘含量的关系；方法：检测新疆医科大学第一附属 医院健康体检中心2010年3月至7月的470例体检人群的血清三碘甲状腺原氨酸（T3）、 甲状腺素（T4）、促甲状腺激素（TSH），甲状腺球蛋白抗体（TGab）、甲状腺微 粒体抗体（TMab）、并对其进行甲状腺超声检测。根据检测结果分为病例组与正常 对照组，检测两组的尿碘含量，对两组数据及相关的临床资料进行统计分析。结果： 1.病例组的尿碘中位数明显高于正常对照组，两组间采用Wilcoxon秩和检验比较，差 异有显著性意义（P0.01）；2.病例组中不同甲状腺疾病组尿碘浓度均明显高于正常 对照组；尿碘浓度300ug/l，不同甲状腺疾病组的构成比明显高于正常对照组；甲状 腺功能异常组、甲状腺结节组、抗体阳性组分别与正常对照组比较尿碘浓度100ug/l、 100~ 200ug/l、200~300ug/l、300ug/l构成比（P0.01），差异具有统计学意义；3.TSH 增高组（10uIU/ml）和TSH降低组（2.2uIU/ml）尿碘中位数明显高于TSH正常组 （2.2~10ug/l）；TSH增高组、降低组分别与TSH正常组比较不同尿碘浓度构成比，采 用Wilcoxon秩和检验（P0.01），差异具有统计学意义；结论:1.正常人群碘足量，甲 状腺疾病患者碘过量；2.促甲状腺激素的水平变化与高尿碘有关；3.甲状腺疾病的发 病与高尿碘有关；4.补碘因根据当地的碘环境, 结合个体差异,科学合理的补碘。 关键词：尿碘；甲状腺疾病；甲状腺结节；甲状腺功能 INVESTIGATE THE RELATIONSHIP OF THYROID DISEASES AND UFJN IODINE Postgraduate: Han Yuanyuan Supervisor: Associate prof. Fan Yong ABSTRACT Objective: The case group and control group by detecting thyroid hormones, thyroid stimulating hormone, thyroid ultrasound and urinary iodine content, its data for statistical analysis of thyroid disease and the relationship between urinary iodine.Methods: Detection of the case group and control group in T3、T4、TSH、thyroid ultrasound and urine iodine ,detected on the two sets of data and relevant clinical data for statistical analysis.Results:1.patient group the median urinary iodine was significantly higher than the control group，Between the two groups using Wilcoxon rank sum test, the difference was significant ( Ζ = 13.042, P 0.01); 2.Patient group with different thyroid diseases of urinary iodine concentration was significantly higher than the control group, urinary iodine concentration of 300ug/l, the composition of different groups of thyroid disease was significantly higher than the control group; with urinary iodine concentration increased, the constituent ratio of each patient group showed a growth trend. Abnormal thyroid function, thyroid nodules group, goiter group compared with the