尖叶假龙胆防治ISO诱导的急性心肌损伤的作用机制 研究-生物化学与分子生物学专业论文.docxVIP

万方数据 万方数据 目 录 中文摘要···········································································································1 英文摘要···········································································································5 英文缩写············································································································9 研究论文 尖叶假龙胆防治 ISO 诱导的急性心肌损伤的作用机制研究 前言··········································································································11 材料与方法······························································································13 结果··········································································································22 附图··········································································································25 附表··········································································································33 讨论··········································································································34 结论··········································································································37 参考文献··································································································38 综述 TLR4/NF-кB 信号通路在心肌损伤中的作用····································43 致谢··················································································································54 个人简历··········································································································56 中 中 文 摘 要 PAGE 10万方数据 PAGE 10 万方数据 尖叶假龙胆防治 ISO 诱导的急性心肌损伤的作用机制研究 摘 要 心血管疾病已经成为世界上导致死亡的主要原因之一。急性心肌梗死 是心血管疾病中最常见的一种，是心血管疾病中主要死亡原因之一。心肌 梗死会导致心肌缺血，如不及时治疗，心肌缺血将会造成严重的心肌损伤 和心脏功能障碍，甚至于猝死。但是目前尚缺乏有效的防治手段。因此， 研究急性心肌损伤的发病原因和有效的防治手段已经成为了全世界关注 的热门问题之一。异丙肾上腺素（Isoproterenol，ISO）是儿茶酚胺类的β 受体阻断剂，在大剂量注射后可引起动物的急性心肌损伤，这类似于人类 由于心肌缺血引起心肌梗死后的急性心肌损伤，因此成为本实验造模的基 础。尖叶假龙胆（Gentianella acuta (Michx.) Hulten，Gentianella acuta，G.） 是龙胆科假龙胆属的植物，主要分布于河北， 、东北， 、山